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Sentinel lymph node biopsy using single-agent mapping tracer (blue dye) after neoadjuvant chemotherapy in a Brazilian cohort of breast cancer patients. Real world evidence
Department of OncologyResende, Heloisa Magda; Lichtenfels, Martina; Soares, Igor Camargo; Renó, Angélica Araújo Cortines Laxe; Cunha, Ana Paula; Falcão, Pedro Gustavo; Pieroni, Carolina Soares Pimentel; Department of OncologyAssis, Biazi Ricieri de; Cardoso, Paola; Marassi, Pedro Henrique Adário; Reis, Rafael dos Santos.
Afiliação
  • Department of OncologyResende, Heloisa Magda; Centro Universitário de Volta Redonda. Hospital Jardim Amália. Department of OncologyResende, Heloisa Magda. Volta Redonda. BR
  • Lichtenfels, Martina; Hospital São Lucas. Breast Cancer Center. Porto Alegre. BR
  • Soares, Igor Camargo; Hospital Jardim Amália. Department of Mastology. Volta Redonda. BR
  • Renó, Angélica Araújo Cortines Laxe; Hospital Jardim Amália. Department of Mastology. Volta Redonda. BR
  • Cunha, Ana Paula; Hospital Jardim Amália. Department of Mastology. Volta Redonda. BR
  • Falcão, Pedro Gustavo; Laboratório Falcão. Volta Redonda. BR
  • Pieroni, Carolina Soares Pimentel; Hospital Jardim Amália. Department of Oncology. Volta Redonda. BR
  • Department of OncologyAssis, Biazi Ricieri de; Centro Universitário de Volta Redonda. Hospital Jardim Amália. Department of OncologyAssis, Biazi Ricieri de. Volta Redonda. BR
  • Cardoso, Paola; Centro Universitário de Volta Redonda. School of Medicine. Volta Redonda. BR
  • Marassi, Pedro Henrique Adário; Centro Universitário de Volta Redonda. School of Medicine. Volta Redonda. BR
  • Reis, Rafael dos Santos; Centro Universitário de Volta Redonda. School of Medicine. Volta Redonda. BR
Acta cir. bras ; 36(6): e360608, 2021. tab, graf
Article em En | LILACS, VETINDEX | ID: biblio-1278115
Biblioteca responsável: BR1.1
ABSTRACT
ABSTRACT Purpose To reduce false-negative rates (FNR) in sentinel lymph node biopsy (SLNB) of clinically positive (cN+) axilla in patients undergoing neoadjuvant chemotherapy (NAC). The removal of three or more lymph nodes with dual-tracer mapping including a radioisotope was used. However, in the Brazilian Unified Health System, the radioisotope tracer is not feasible in some hospitals. We conducted a cross-sectional study to evaluate the detection rate of sentinel lymph node (SLN) in patients who converted from cN+ to ycN0 after NAC using blue dye as a single-agent mapping tracer. Methods During the period of March 2018 to September 2019, 34 patients who underwent NAC with cN+ who converted to ycN0 were enrolled in the study. The SLNB was performed using blue dye as a single-agent mapping followed by axillary lymph node dissection (ALND). Results The detection rate of sentinel lymph node was of 85.3%, being SLNB not possible for five patients (14.7%), due to fibrosis. The mean number of removed SLN was 2.5. Conclusions The use of blue dye as a single-agent mapping tracer demonstrated an acceptable detection rate of 85.3%. Although the FNR was possible to be determined, the small sample size might overestimate this rate. The removal of three or more lymph nodes with single-agent mapping tracer might be indicated for breast cancer patients who converted to ycN0 after NAC in the Brazilian health public services, in which radioisotope tracer is not suitable.
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Texto completo: 1 Base de dados: LILACS / VETINDEX Idioma: En Revista: Acta cir. bras Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: LILACS / VETINDEX Idioma: En Revista: Acta cir. bras Ano de publicação: 2021 Tipo de documento: Article