Your browser doesn't support javascript.
loading
Inflammation: improving understanding to prevent or ameliorate kidney diseases
Fernandes, Sheila Marques; Watanabe, Mirian; Vattimo, Maria de Fátima Fernandes.
Afiliação
  • Fernandes, Sheila Marques; University of São Paulo. School of Nursing. Animal Model Experimental Laboratory. São Paulo. BR
  • Watanabe, Mirian; University of São Paulo. School of Nursing. Animal Model Experimental Laboratory. São Paulo. BR
  • Vattimo, Maria de Fátima Fernandes; University of São Paulo. School of Nursing. Animal Model Experimental Laboratory. São Paulo. BR
J. venom. anim. toxins incl. trop. dis ; 27: e20200162, 2021. tab, graf
Article em En | LILACS, VETINDEX | ID: biblio-1346434
Biblioteca responsável: BR68.1
ABSTRACT
Inflammatory processes are believed to play an important role in immune response to maintain tissue homeostasis by activating cellular signaling pathways and releasing inflammatory mediators in the injured tissue. Although acute inflammation can be considered protective, an uncontrolled inflammation may evolve to tissue damage, leading to chronic inflammatory diseases. Inflammation can be considered the major factor involved in the pathological progression of acute and chronic kidney diseases. Functional characteristics of this organ increase its vulnerability to developing various forms of injuries, including acute kidney injury (AKI) and chronic kidney disease (CKD). In view of translational research, several discoveries should be considered regarding the pathogenesis of the inflammatory process, which results in the validation of biomarkers for early detection of kidney diseases. Biomarkers enable the identification of proinflammatory mediators in kidney affections, based on laboratory research applied to clinical practice. Some inflammatory molecules can be useful biomarkers for the detection and diagnosis of kidney diseases, such as neutrophil gelatinase-associated lipocalin, kidney injury molecule-1 and interleukin 18.(AU)
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: LILACS / VETINDEX Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: LILACS / VETINDEX Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Ano de publicação: 2021 Tipo de documento: Article