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Evaluation of a new additive-dominance genomic model and implications for quantitative genetics and genomic selection

Miranda, Taiana Lopes Rangel; Resende, Marcos Deon Vilela de; Azevedo, Camila Ferreira; Nunes, Andrei Caíque Pires; Takahashi, Elizabete Keiko; Simiqueli, Guilherme Ferreira; Silva, Fabyano Fonseca e; Alves, Rodrigo Silva.
Sci. agric; 79(6): e20210074, 2022. tab, graf
Artigo em Inglês | VETINDEX | ID: biblio-1347911

Resumo

The Fisher's infinitesimal model is traditionally used in quantitative genetics and genomic selection, and it attributes most genetic variance to additive variance. Recently, the dominance maximization model was proposed and it prioritizes the dominance variance based on alternative parameterizations. In this model, the additive effects at the locus level are introduced into the model after the dominance variance is maximized. In this study, the new parameterizations of additive and dominance effects on quantitative genetics and genomic selection were evaluated and compared with the parameterizations traditionally applied using the genomic best linear unbiased prediction method. As the parametric relative magnitude of the additive and dominance effects vary with allelic frequencies of populations, we considered different minor allele frequencies to compare the relative magnitudes. We also proposed and evaluated two indices that combine the additive and dominance variances estimated by both models. The dominance maximization model, along with the two indices, offers alternatives to improve the estimates of additive and dominance variances and their respective proportions and can be successfully used in genetic evaluation.
Biblioteca responsável: BR68.1