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Oxidative stress, ceruloplasmin and neopterin biomarkers in dromedary camels with clinical endometritis
El-Deeb, Wael; Abdelghani, Mohammed Ali; Alhaider, Abdulrahman; Fayez, Mahmoud.
Afiliação
  • El-Deeb, Wael; Mansoura University. Faculty of Veterinary Medicine. Department of Internal Medicine, Infectious Diseases and Fish Diseases. Mansoura. EG
  • Abdelghani, Mohammed Ali; Assuit University. Faculty of Veterinary Medicine. Department of Theriogenology. Assuit. EG
  • Alhaider, Abdulrahman; King Faisal University. College of Veterinary Medicine. Department of Clinical Sciences. Al-Ahsa. SA
  • Fayez, Mahmoud; Ministry of Environment, Water and Agriculture. Al Ahsa Veterinary Diagnostic Laboratory. Al Ahsa. SA
Anim. Reprod. (Online) ; 19(3): e20220035, set. 2022. ilus, graf, tab
Article em En | VETINDEX | ID: biblio-1393230
Biblioteca responsável: BR68.1
ABSTRACT
The purpose of this study is to investigate the role of some oxidative stress (OS), ceruloplasmin (Cp), and neopterin (NPT) as diagnostic biomarkers for dromedary camels endometritis as well as to explore the impact of ceftiofur treatment on endometritis. Camels were categorized into two groups; healthy control group (n = 20) and endometritis group (n = 60). She-camels with clinical signs of endometritis (CE) received 6.6 mg/kg BW of ceftiofur (i/m). On days 7, and 14, she-camels were evaluated and clinical cure or failure to cure was determined. The comparison of the groups for OS demonstrated that endometritis caused an increase in serum malondialdehyde (sMDA), Cp, and NPT levels (P<0.05), but decreased serum levels of superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) (P<0.05). The most prevalent pathogens involved in the etiology of CE are Arcanobacterium pyogenes, Streptococcus pyogenes, and Staphylococcus aureus. All examined biomarkers demonstrated a high degree of recognition between CE camel and healthy controls (the area under the curve (AUC) was 95.9 for NPT). A higher proportion of camels with CE that were treated with ceftiofur (90%, P<0.0001) showed clinical cure by the first dose, while 10% required a second dose. In conclusion, CE causes increased oxidative reactions and decreased antioxidant defense competence. Subsequently, the alteration in that balance that was represented by the biomarkers of OS could be beneficial for clinical practice and basic clinical research. Additionally, all trials demonstrated the efficacy of ceftiofur for the treatment of CE in she-camel.(AU)
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Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: Anim. Reprod. (Online) Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: Anim. Reprod. (Online) Ano de publicação: 2022 Tipo de documento: Article