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Assessment of stress and anxiety in mice with colorectal cancer submitted to physical exercise
Silva Junior, Udenilson Nunes da; Boutrik, Amanda; Gonçalves, Alessandra de Figueiredo; Neves, Marcelo Barbosa; Alves, Gabriela Rodrigues; Fagundes, Letícia Silva; Abreu, Antônio Carlos de; Aydos, Ricardo Dutra; Ramalho, Rondon Tosta.
Afiliação
  • Silva Junior, Udenilson Nunes da; Universidade Federal do Mato Grosso do Sul. Faculty of Medicine. Campo Grande. BR
  • Boutrik, Amanda; Universidade Federal do Mato Grosso do Sul. Faculty of Medicine. Campo Grande. BR
  • Gonçalves, Alessandra de Figueiredo; Universidade Federal do Mato Grosso do Sul. Postgraduate Program in Health and Development in the Midwest Region. Campo Grande. BR
  • Neves, Marcelo Barbosa; Universidade Federal do Rio de Janeiro. Postgraduate Program in Biological Sciences. Rio de Janeiro. BR
  • Alves, Gabriela Rodrigues; Universidade Federal do Mato Grosso do Sul. Postgraduate Program in Health and Development in the Midwest Region. Campo Grande. BR
  • Fagundes, Letícia Silva; Universidade Federal do Mato Grosso do Sul. Postgraduate Program in Health and Development in the Midwest Region. Campo Grande. BR
  • Abreu, Antônio Carlos de; Universidade Federal do Mato Grosso do Sul. Postgraduate Program in Health and Development in the Midwest Region. Campo Grande. BR
  • Aydos, Ricardo Dutra; Universidade Federal do Mato Grosso do Sul. Postgraduate Program in Health and Development in the Midwest Region. Campo Grande. BR
  • Ramalho, Rondon Tosta; Universidade Federal do Mato Grosso do Sul. Postgraduate Program in Health and Development in the Midwest Region. Campo Grande. BR
Acta cir. bras ; 37(5): e370508, 2022. graf, ilus
Article em En | VETINDEX | ID: biblio-1393758
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT

Purpose:

To evaluate the effect of physical exercise on the behavior of rodents with colorectal cancer induced through the use of elevated plus maze.

Methods:

We used 40 male hairless mice induced to colorectal cancer, divided into five groups G1) submitted to pre- and post-induction swimming; G2) pre- and post-induction ladder; G3) post-induction swimming; G4) post-induction ladder; G5) sedentary. At the end of the 14th week, the animals were submitted to the plus maze test.

Results:

The mean length of stay in the open arm for G1 was 4.17 ± 6.50; G2 37.52 ± 40.7; G3 85.84 ± 42.5; G4 32.92 ± 23.17; and G5 4.09 ± 4.43. In the closed arm, it was 264 ± 23.43 in G1, 187.60 ± 47.73 in G2, 147.50 ± 40.03 in G3, 182.00 ± 40.40 in G4, and in G5 235.36 ± 14.28. In the center, G1 remained 31.86 ± 20.18, G2 74.85 ± 28.37, G3 66.69 ± 19.53, G4 60.55 ± 10.46, and G5 60.55 ± 23.65.

Conclusions:

Aerobic exercise for seven weeks after tumor induction showed less impact on the behavior of the animals. On the other hand, it significantly increased the animals' stress level when applied for 14 weeks before and after tumor induction. Key words
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Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: Acta cir. bras Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: Acta cir. bras Ano de publicação: 2022 Tipo de documento: Article