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Histopathological and Immunophenotypical Analysis of Canine Mucinous Rectal Adenocarcinoma

Damasceno, Karine Araújo; Rabelo, Bruna Salgado; Gamba, Conrado de Oliveira; Souza, Cristina Maria de; Campos, Liliane Cunha; Campos, Cecília Bonolo de; Ferreira, Enio; Cassali, Geovanni Dantas.
Braz. j. vet. pathol; 5(2): 74-77, jul. 2012. ilus
Artigo em Inglês | VETINDEX | ID: biblio-1397778

Resumo

Rectal adenocarcinomas are uncommon in dogs and usually present poor prognosis. The present work describes the morphological and immunophenotypical findings of a rectal mucinous adenocarcinoma in a bitch. Histological analysis revealed a malignant epithelial proliferation in a tubulopapillary pattern forming multiple intratubular cell layers. Moderate amount of PAS-positive amorphous eosinophilic content within neoplastic tubules and extruded into the stroma was observed. Immunohistochemical analysis revealed neoplastic cells considered positive for cytokeratin, Her-2, COX-2 and E-caderin and with low p53 expression. A high proliferation index was observed. Based on histological and immunophenotypical findings, the diagnosis of mucinous adenocarcinoma was established.(AU)
Biblioteca responsável: BR68.1