Tissue healing changes on wounds in rats after treatment with Hancornia speciosa latex in cream-gel formulation
D'Abadia, Patrícia Lima; Lemes, Susy Ricardo; Melo-Reis, Paulo Roberto de; Lino Júnior, Ruy de Souza; Gonçalves, Pablo José; Reis, Diego dos Santos; Caixeta, Graziele Alícia Batista; Amaral, Vanessa Cristine Santana; Almeida, Luciane Madureira.
Acta cir. bras;
37(10): e371001, 2022. ilus, graf, tab
Artigo
em Inglês
| VETINDEX
| ID: biblio-1415422
Resumo
Purpose: Hancornia speciosa latex has shown pharmacological potential in wound healing processes due to its angiogenic, osteogenic, and anti-inflammatory activities. The aims of this study were to carry out a cream-gel formulation with 5, 10 and 25% of H. speciosa serum latex and to evaluate its potential to stimulate the skin regeneration in rats' wounds. Methods: One hundred and twenty rats were divided into five groups: neutral control with saline (G1), cream-gel based on H. speciosa latex serum at 5% m/v (G2), cream-gel at 15% m/v (G3), cream-gel at 25% m/v (G4), and cream-gel (G5). The animals were euthanized at three, seven, 14 and 21 days after the injury induction, and some parameters were analyzed: wound contraction, necrosis, fibrin, polymorphonuclear and mononuclear infiltrates, fibroblast, angiogenesis, hemorrhage, and collagen. Results:The therapeutic treatment with cream-gel at 15 and 25% is beneficial in the inflammatory phase of healing processes since it increased the angiogenesis and proliferation of mononuclear infiltrations in wounds. Regarding wound contraction, the treatment with cream-gel (5 and 15%) induced a higher rate of contraction in the proliferative phase. The 15% cream-gel formulation stimulated a greater production of collagen in the injured tissues. Conclusions: H. speciosa cream-gel is a low-cost herbal medicine which can aid in tissue repair.
Biblioteca responsável:
BR68.1
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