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Reproductive toxicity assessment of Origanum vulgare essential oil on male Wistar rats
Hollenbach, Clarissa Boemler; Bing, Rafaela Scheer; Stedile, Rafael; Mello, Fabíola Peixoto da Silva; Schuch, Tatiana Larissa; Rodrigues, Maria Regina Alves; Mello, Fernanda Bastos de; Mello, João Roberto Braga de.
Afiliação
  • Hollenbach, Clarissa Boemler; Universidade Federal do Rio Grande do Sul. Pharmacology Department. Porto Alegre. BR
  • Bing, Rafaela Scheer; Universidade Federal do Rio Grande do Sul. Pharmacology Department. Porto Alegre. BR
  • Stedile, Rafael; Universidade Federal do Rio Grande do Sul. Pharmacology Department. Porto Alegre. BR
  • Mello, Fabíola Peixoto da Silva; Universidade Federal do Rio Grande do Sul. Pharmacology Department. Porto Alegre. BR
  • Schuch, Tatiana Larissa; Universidade Federal do Rio Grande do Sul. Pharmacology Department. Porto Alegre. BR
  • Rodrigues, Maria Regina Alves; Universidade Federal de Pelotas. Organic Chemistry Department. BR
  • Mello, Fernanda Bastos de; Universidade Federal de Ciências da Saúde de Porto Alegre. Basic Health Science Department. Porto Alegre. BR
  • Mello, João Roberto Braga de; Universidade Federal do Rio Grande do Sul. Pharmacology Department. Porto Alegre. BR
Acta sci. vet. (Impr.) ; 43: Pub.1295-2015. tab, graf
Article em En | VETINDEX | ID: biblio-1457328
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT

Background:

The oregano essential oil (Origanum vulgare L.) is rich in phenolic compounds with therapeutic actionssuch as antimicrobial, antifungal and antioxidant. Based on the therapeutic potential and clinical use of oregano essentialoil, in vivo toxicology studies of oregano essential oil are scarce and the current researches focus on the genotoxicity ofseveral species of oregano; however, toxicological and complementary studies are needed to ensure safety of formulationscontaining this oil. Through values of Minimum Inhibitory Concentration (MIC) of oregano essential oil against Candidaspecies, and increased in an exponential scale, the initial dose was obtained. This study aims to evaluate male fertilitythrough the reproductive aspects of rats chronically treated with oregano essential oil.Materials, Methods &

Results:

The rats were divided into five groups with 10 males and 30 females each; three groupswere treated with oregano essential oil at a concentration of 3% Vol/Vol (GO3%), of 9% Vol/Vol (GO9%) and of 27% Vol/Vol (GO27%). The negative control group received the vehicle, 0.001% Vol/Vol Tween 80 (GC-) and the positive controlgroup was treated with thymol and terpinen-4-ol, at the same concentration found in the oregano essential oil, detected bygas chromatography (3% + 3% Vol/Vol) (GC+). Animals were allowed to adapt for at least ten days before the beginningof the experiment. They were maintained under...
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Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: Acta sci. vet. (Impr.) Ano de publicação: 2015 Tipo de documento: Article
Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: Acta sci. vet. (Impr.) Ano de publicação: 2015 Tipo de documento: Article