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Hemangiossarcoma metastático em uma vaca / Metastatic hemangiosarcoma in a cow

Pereira, Gabriela Oliveira; Carvalho, Nathalia da Silva; Retamero, Paula Dias; Oliveira, Mariana Correia; Lorenzo, Cintia De; Brito, Marilene de Farias; Ubiali, Daniel Guimarães.
Acta sci. vet. (Impr.); 46(supl): 1-5, 2018. ilus
Artigo em Português | VETINDEX | ID: biblio-1457946

Resumo

Background: Hemangiosarcoma is a malignant mesenchymal neoplasm of endothelial cells that mainly affects dogs and is less common in horses, cattle, goats, pigs, and sheep. In ruminants, however, few cases of hemangiosarcoma have been reported. Although this neoplasm may primarily occur in any tissue, it most often originates in the spleen, liver, heart, and skin. This study reports the clinical and pathological findings of a bovine hemangiosarcoma.Case: A 10-year-old lactating Girolando cow from the municipality of Vassouras/RJ was examinated because of uncontrolled cough and bilateral hemoptysis, loss of appetite, fever, weight loss, severe decline in milk production (a decrease of 28 L), and respiratory wheezing during chest auscultation. We performed a necropsy and collected fragments of various organs which were fixed using 10% buffered formalin and sent to the Pathology Anatomy Sector (SAP) of the Federal Rural University of Rio de Janeiro (UFRRJ) for routine histological assessment. Macroscopically, large hemorrhagic areas were observed in the lungs, mainly in the cranioventral portion of the pulmonary lobes, multifocal areas of hemorrhages in the liver, and a 10x8x5 cm soft red mass was observed in the spleen. Microscopically, was observed lung proliferation of endothelial cells arranged in tapes, supported by a collagenous stroma associated with severe multifocal lobular hemorrhage with a large number of siderophages and diffuse and marked edema, and congestion. In the mediastinal lymph node, liver, and spleen, the proliferation of neoplastic endothelial cells equivalent to those described in the lungs was observed. The histological sections of liver and tumor spleen were subjected to immunohistochemical analysis for von Willebrand factor, in which marking was observed in neoplastic endothelial cells.[...]
Biblioteca responsável: BR68.1
Localização: BR68.1