Hemangioma cavernoso cerebral em cão / Cerebral cavernous hemangioma in a dog

ABSTRACT

Background: Cerebral cavernous hemangioma is a rare neoplasm of vascular origin in the brain, characterized by abnormally dilated vascular channels surrounded by endothelium without muscle or elastic fibers. Presumptive diagnosis isperformed by magnetic resonance or computed tomography (CT) scanning and can be confirmed by histopathology. Theprognosis of intracranial cavernous hemangioma is poor, with progression of clinical signs culminating in spontaneousdeath or euthanasia. The purpose of this paper is to report a case of cerebral cavernous hemangioma in a dog, presentingthe clinical findings, tomographic changes, and pathological findings.Case This case involved a 2-year-old medium sized mixed breed female dog presenting with apathy, hyporexia, ataxia,bradycardia, dyspnea, and seizure episodes for three days. Hemogram and serum biochemistry of renal and hepatic function and urinalysis did not reveal any visible changes. CT scanning was also performed. The scans revealed a hyperdensenodule of 15.9 x 14 mm, with well defined borders, and a hypodense halo without post-contrast enhancement and masseffect in the right parietal lobe was observed in both transverse and coronal sections. Based on the image presented in theCT scans, the nodule was defined as a hemorrhagic brain lesion. The animal died after a seizure. The right telencephalonwas subjected to necropsy, which revealed a reddish-black wel-defined nodule 1.7 cm in diameter extending from theheight of the piriform lobe to the olfactory trine at the groove level and extending towards the lateral ventricle, with slightcompression and deformation of the thalamus but no other macroscopic alterations in the other organs. The histopathologyindicated that this nodular area in the encephalus contained moderate, well-delimited but unencapsulated cellularity, composed of large vascular spaces paved with endothelial cells filled with erythrocytes, some containing eosinophilic fibrillarmaterial ...