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Effect of parenteral vaccination of newborn Holstein calves against viral agents involved in bovine respiratory disease (BRD)
Gomes, Viviani; Gonzalez, Diego Daniel; Madureira, Karina Medici; Mozgovoj, Marina Valeria; Baccili, Camila Costa; Silva, Bruno Toledo; Ramos, Jean Silva; Silva, Karen Nascimento; Pituco, Edviges Maristella.
Afiliação
  • Gomes, Viviani; Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia. São Paulo. BR
  • Gonzalez, Diego Daniel; Instituto Nacional de Tecnología Agropecuaria. Buenos Aires. AR
  • Madureira, Karina Medici; Universidade Federal da Bahia. Escola de Medicina Veterinária e Zootecnia. Salvador. BR
  • Mozgovoj, Marina Valeria; Instituto Nacional de Tecnología Agropecuaria. Buenos Aires. AR
  • Baccili, Camila Costa; Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia. São Paulo. BR
  • Silva, Bruno Toledo; Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia. São Paulo. BR
  • Ramos, Jean Silva; Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia. São Paulo. BR
  • Silva, Karen Nascimento; Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia. São Paulo. BR
  • Pituco, Edviges Maristella; Instituto Biológico. São Paulo. BR
Acta sci. vet. (Impr.) ; 48: Pub.1757-Jan. 30, 2020. tab
Article em En | VETINDEX | ID: biblio-1458280
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT

Background:

Newborn calves are born immunosuppressed, hypogammaglobulinemic, immunologically immature, and therefore more vulnerable to many infectious diseases. During pregnancy, the fetal-placental environment is regulated by Th2-type cytokines that neutralize Th1 responses, an important factor for immune defense against viral agents. The ingestion and absorption of colostral immunoglobulins enhance the immunity of the neonate. However, the presence of maternal antibodies might negatively affect the success of parental vaccination in the first two months of life. This study aimed to evaluate the effecacy of parenteral vaccination in newborn calves with high titers of maternal antibodies against respiratory viruses. Materials, Methods &

Results:

Twenty-eight Holstein calves were allocated to the vaccinated group (VAC, n = 18) or an unvaccinated control group (NVAC, n = 10). The initial vaccination with 5 mL of a commercial vaccine occurred around the 14th day of life (D14) and the booster at D35. Respiratory and diarrhea symptoms were evaluated at D12, D14, D16, D20, D31, D36, D45, D53, and D60. Blood samples were taken for leukogram, haptoglobin, and seroneutralization of BVDV, BoHV-1, BRSV, and BPI3V, at the time of vaccination at D14 (T1), at booster (D35, T2), and 21 days after the booster (D56, T3). Despite the increased prevalence of BRD during the period of the study, no calves from either group exhibited respiratory disease at D12 or D14. In subsequent assessments, the frequency of BRD increased over time in the VAC group until it reached a maximum prevalence of 38.9% (7/18) at D31. In the NVAC group, the maximum prevalence observed was 40% at D45 and D60. A comparison of the frequencies for BRD cases showed a statistical trend at D36 (P = 0.07), with a higher prevalence for the NVAC group (30%) in relation to the VAC group (5.6%). For the NVAC group, a greater number of total...
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Texto completo: 1 Base de dados: VETINDEX Limite: Animals Idioma: En Revista: Acta sci. vet. (Impr.) Ano de publicação: 2020 Tipo de documento: Article / Project document

Texto completo: 1 Base de dados: VETINDEX Limite: Animals Idioma: En Revista: Acta sci. vet. (Impr.) Ano de publicação: 2020 Tipo de documento: Article / Project document