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Snake venom galactoside-binding lectins: a structural and functional overview
Sartim, Marco A; Sampaio, Suely V.
Afiliação
  • Sartim, Marco A; Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Departamento de Análises Clínicas, Toxicológicas e Bromatológicas. Ribeirão Preto. BR
  • Sampaio, Suely V; Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Departamento de Análises Clínicas, Toxicológicas e Bromatológicas. Ribeirão Preto. BR
J. venom. anim. toxins incl. trop. dis ; 21: 35, 31/03/2015. tab, graf, ilus
Article em En | LILACS, VETINDEX | ID: biblio-954748
Biblioteca responsável: BR68.1
ABSTRACT
Snake venom galactoside-binding lectins (SVgalLs) comprise a class of toxins capable of recognizing and interacting with terminal galactoside residues of glycans. In the past 35 years, since the first report on the purification of thrombolectin from Bothrops atrox snake venom, several SVgalLs from Viperidae and Elapidae snake families have been described, as has progressive improvement in the investigation of structural/functional aspects of these lectins. Moreover, the advances of techniques applied in protein-carbohydrate recognition have provided important approaches in order to screen for possible biological targets. The present review describes the efforts over the past 35 years to elucidate SVgalLs, highlighting their structure and carbohydrate recognition function involved in envenomation pathophysiology and potential biomedical applications.(AU)
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Texto completo: 1 Base de dados: LILACS / VETINDEX Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: LILACS / VETINDEX Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Ano de publicação: 2015 Tipo de documento: Article