Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide
Fernandes, Tania Rita Moreno de Oliveira; Santos, Itamar; Korinsfky, Juliana Pedrosa; Silva, Benedyto Savio Lima e; Carvalho, Luis Otavio; Plapler, Helio.
Acta cir. bras.;
29(1): 7-15, 01/2014. tab, graf
Artigo
em Inglês
| VETINDEX
| ID: vti-10199
Resumo
PURPOSE: To study the possible potentiation of the carcinogenic effects of ultraviolet radiation associated with an organophosphate pesticide. METHODS: Forty Wistar rats were assigned into four groups (n=10 each) randomized according to the procedures: group A received only UVR-B radiation; group B, UVR-B for eight weeks followed by a seven week period of pesticide exposure; group C, UVR-B + pesticide concomitantly: group D, only pesticide application. At the end of the fifth, tenth and fifteenth weeks the animals were photographed. Skin biopsy and histopathological study with Hematoxylin-Eosin were done on the fifteenth week. Statistical analysis with Fisher's and Sign (unilateral) tests, 5% value for significance. RESULTS: Macroscopic lesions in the group A evolved from the erythema to erythema + desquamation. The groups B and C, with the association of two carcinogens, and group D presented evolution to keratosis, with higher incidence in group D. The histology showed a significant increase in the severity of injuries when the UVR-B and the pesticide were applied simultaneously, leading to cellular atypia. CONCLUSIONS: Concurrent association of UVR-B to organophosphate pesticide produced more severe lesions microscopically, although this has not been so apparent macroscopically. In daily practice the clinical evaluation should be complemented with laboratory evaluation. .(AU)
Biblioteca responsável:
BR1.1
Localização: BR68.1
Texto completo