Your browser doesn't support javascript.

Portal de Pesquisa da BVS Veterinária

Informação e Conhecimento para a Saúde

Home > Pesquisa > ()
Imprimir Exportar

Formato de exportação:

Exportar

Exportar:

Email
Adicionar mais destinatários

Enviar resultado
| |

The ileum positively regulates hepatic regeneration in rats

Medeiros, Aldo Cunha; Azevedo, Ana Clara Batista; Oseas, Jessica Mayara de Figueiredo; Gomes, Mariana Davim Ferreira; Oliveira, Fernanda Gurgel de; Rocha, Keyla Borges Ferreira; Azevedo, Italo Medeiros; Rego, Amalia Cinthia Meneses; Carvalho, Marilia Daniela Ferreira.
Acta cir. bras.; 29(2): 93-98, 02/2014. tab, graf
Artigo em Inglês | VETINDEX | ID: vti-10204

Resumo

To test the hypothesis that liver regeneration after partial hepatectomy can be influenced by the ileum. METHODS: Eighteen Wistar rats were distributed into groups of six animals: 1 - ileum resection+ hepatectomy 2/3; 2 - hepatectomy 2/3, and 3 - sham. Anesthesia with ketamine and xylazine i.p., aseptic technique, analgesia with meperidine (10mg/kg s.c.). On day 6, serum ALT, AST, alkaline phosphatase (AP) and albumin were measured. Liver regeneration and hepatocyte mitosis were quantified. Statistical analysis with ANOVA and Tukey tests, with significance p<0.05. RESULTS: In group hepatectomy+ileal resection, ALT, AST and AP were 180.6±24.9, 58.6±3.1 and 254.6±46.6 respectively. They were significantly higher than in the hepatectomy group, whose values were 126.0±16.5, 44.1±3.9 and 163.5±8.6, respectively (p<0.001). Albumin levels were not significantly different among groups. Liver regeneration in hepatectomy group (94.17%) was statistically higher (p<0.001) than in ileal resection+hepatectomy group (55.96%). In the latter group the mitosis of hepatocytes were significantly less frequent than in the hepatectomy group. CONCLUSION: The data confirm that the ileum positively influence on liver regeneration in rats undergoing hepatectomy.(AU)
Biblioteca responsável: BR1.1
Localização: BR68.1