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Behavioural and cognitive effects of simvastatin dose used in stimulation of bone regeneration in rats
Sousa, Dircilei Nascimento de; Santana, Washington Macedo de; Ferreira, Vania Moraes; Duarte, Wagner Rodrigues.
Afiliação
  • Sousa, Dircilei Nascimento de; Universidade de Brasilia. Faculdade de Ciências da Saúde. Brasilia. Brasil
  • Santana, Washington Macedo de; Universidade de Brasilia. Faculdade de Ciências da Saúde. Brasilia. Brasil
  • Ferreira, Vania Moraes; Universidade de Brasilia. Faculdade de Ciências da Saúde. Brasilia. Brasil
  • Duarte, Wagner Rodrigues; Universidade de Brasilia. Faculdade de Ciências da Saúde. Brasilia. Brasil
Acta cir. bras. ; 29(3): 151-157, 03/2014. graf
Article em En | VETINDEX | ID: vti-10217
Biblioteca responsável: BR1.1
Localização: BR68.1
ABSTRACT
To analyze the effects of simvastatin (SVT) in the locomotion, anxiety and memory of rats, as a reflection of the administration of a minimum dose capable of stimulating bone regeneration in defects in the calvariae.

METHODS:

Surgical procedures were performed in 15 female Wistar rats, 2-month old, to insert the grafting material regenerator (Bone-ceramic(r)) and/or SVT, followed by behavioural and cognitive assessments in the 7th, 30th and 60th days post surgery.

RESULTS:

The SVT locally applied with the goal of bone regeneration in defects created in rat calvariae does not interfere with locomotion, anxiety levels and/or memories of rats, except for the first week following surgery, when an anxiolytic effect was observed, as a result of a possible central action.

CONCLUSION:

Failure to provoke any response within 30 and 60 days post surgical procedures suggests that SVT may constitute a good choice in stimulating bone regeneration without affecting the long term neural functions.(AU)
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Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: Acta cir. bras. Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: Acta cir. bras. Ano de publicação: 2014 Tipo de documento: Article