Effects of milk from goat fed Crotalaria spectabilis seeds on growing rats / Efeitos da administração de ração contendo leite de cabra alimentada com sementes de Crotalaria spectabilis a ratos em crescimento
Braz. j. vet. res. anim. sci
; 36(2): 97-100, 1999. ilus, tab
Article
em En
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| ID: vti-11028
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BR68.1
Localização: BR68.1
ABSTRACT
Seeds of Crotalaria spectabilis, containing the pyrrolizidine alkaloid (PA) monocrotaline (MCT), were fed to a lactating dairy goat. Milk from this goat was fed to rats for 8 weeks to determine whether MCT or its toxic metabolites are transferred into the goat's milk. Rats from the experimental group showed significantly higher (p<0.05) serum levels of ALT, AST, GGT and LDH and less weight gains (p<0.05) than control rats. The most significant lesions in rats consuming the experimental ration were mild to moderate interstitial pneumonia and a vacuolar degeneration and occasionally necrosis of periportal hepatocytes. The results of this study indicate that the PA and/or its metabolites are eliminated in milk.(AU)
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Idioma:
En
Revista:
Braz. j. vet. res. anim. sci
Ano de publicação:
1999
Tipo de documento:
Article