Effects of milk from goat fed Crotalaria spectabilis seeds on growing rats / Efeitos da administração de ração contendo leite de cabra alimentada com sementes de Crotalaria spectabilis a ratos em crescimento
Medeiros, R M T; Górniak, S L; Guerra, J L.
Braz. j. vet. res. anim. sci;
36(2): 97-100, 1999. ilus, tab
Artigo
em Inglês
| VETINDEX
| ID: vti-11028
Resumo
Seeds of Crotalaria spectabilis, containing the pyrrolizidine alkaloid (PA) monocrotaline (MCT), were fed to a lactating dairy goat. Milk from this goat was fed to rats for 8 weeks to determine whether MCT or its toxic metabolites are transferred into the goat's milk. Rats from the experimental group showed significantly higher (p<0.05) serum levels of ALT, AST, GGT and LDH and less weight gains (p<0.05) than control rats. The most significant lesions in rats consuming the experimental ration were mild to moderate interstitial pneumonia and a vacuolar degeneration and occasionally necrosis of periportal hepatocytes. The results of this study indicate that the PA and/or its metabolites are eliminated in milk.(AU)
Biblioteca responsável:
BR68.1
Localização: BR68.1
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