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Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis

Cavalcante, José Roosevelt; Sampaio, João Paulo Aguiar; Maia Filho, João Tarcísio Alves; Vieira, Renato Braga; Eleutério Júnior, José; Lima Júnior, Roberto César Pereira; Ribeiro, Ronaldo Albuquerque; Almeida, Paulo Roberto Carvalho.
Acta cir. bras.; 29(10): 667-674, 10/2014. tab, graf
Artigo em Inglês | VETINDEX | ID: vti-11148

Resumo

PURPOSE: To investigate E-cadherin immunoexpression during cervical carcinogenesis. METHODS: We assessed the immunohistochemical expression of E-cadherin in squamous intraepithelial lesions (SIL - 52 cases), squamous cell carcinoma (SCC) of the uterine cervix (23 cases) and also in eight cases of cervicitis. RESULTS: The results show very different E-cadherin membrane expression levels when cervicitis (88%), SILs (73%) and SCC (17%) were compared. In SILs, higher E-cadherin loss was seen in less differentiated cells in the basal third of the epithelium. This study suggests that the absence of E-cadherin expression in the membrane is a molecular event that is observed more often in SCC of the uterine cervix than in SILs or cervicitis. CONCLUSIONS: E-cadherin is an essential molecule during the process of cervical carcinogenesis and in this context exhibits a different expression pattern according to the epithelial thickness layer. .(AU)
Biblioteca responsável: BR1.1
Localização: BR68.1