Effect of propranolol on capsular reaction around silicone implants in guinea pigs
Mesquita, Charles Jean Gomes de; Guimarães, Sérgio Botelho; Leite Filhos, José Alberto Dias; Maciel, Felipe Silva; Rocha, José Lima de Carvalho; Leite, José Alberto Dias.
Acta cir. bras.;
30(1): 24-33, 2015.
Artigo
em Inglês
| VETINDEX
| ID: vti-11824
Resumo
PURPOSE: To evaluate the effect of propranolol on capsular architecture around silicone implants by measuring the inflammation, capsular thickness, and collagen fiber density, using a guinea pig experimental model. METHODS: Thirty six adult male guinea pigs randomly divided into two groups (n=18) were used. Each one received a silicone implant with textured-surface. The capsular tissue around implants from untreated or treated animals with the beta-adrenoceptor antagonist propranolol (10 mg/kg, dissolved in daily water) were analyzed for inflammation by histological scoring, capsular thickness by computerized histometry, and collagen fibers type I and Type III density by picrosirius polarization at different time points (7, 14 or 21 days after silicone implantation).RESULTS: Propranolol treatment reduced inflammation and impaired capsular thickness and delayed collagen maturation around the textured implant. CONCLUSION: Propranolol reduces the risk of developing capsular contracture around silicone implants with textured surface.(AU)
Biblioteca responsável:
BR68.1
Localização: BR68.1
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