An evaluation of the protective effect of an infusion of chilled glucose solution on thermal injury of the bile ducts caused by radiofrequency ablation of the liver
Talasso, Marcelo Salim; Lanzoni, Valéria; Goldenberg, Alberto; Garcia, Rodrigo Gobbo; Moura-Franco, Rita Maria Aparecida; Fernandes, Olívia Oléa Cisnero; Mesquita, Rafael de Souza; Carlotto, Jorge Roberto Marcante; matos, Delcio; Lopes-Filho, Gaspar de Jesus; Linhares, Marcelo Moura.
Acta cir. bras.;
30(1): 34-45, 2015.
Artigo
em Inglês
| VETINDEX
| ID: vti-11825
Resumo
PURPOSE: To evaluate the protective effects of chilling the bile ducts with cold (5°C) 5% glucose solution (GS) during radiofrequency (RF) administration. METHODS: Twenty male pigs (3 mos. old; 2530 kg) were subjected to RF delivery with chilling (experimental group, N=10) or without chilling (control group, N=10). Half of the animals in each group were euthanized immediately after the operation, and half were euthanized one week later. The following histological variables in relation to the bile ducts were evaluated by a pathologist (blind examiner): degenerative changes to the epithelium; epithelial necrosis; ulceration, regenerative changes of the epithelium; polymorphonuclear neutrophil infiltration; and thermal effects. RESULTS: The experimental group (88 bile ducts examined) showed reduced thermal damage relative to the control group (86 bile ducts examined) as demonstrated by significant differences in the following histopathological parameters: epithelial detachment of biliary epithelium (84.1% vs. 59.3%; p<0.006); elongation/palisade arrangement of nuclei (65.1% vs. 87.5%; p<0.001); pseudo-goblet cells (32.9% vs. 56.8%; p<0.001). CONCLUSION: Infusion of 5% glucose solution (5°C) has a protective effect on bile ducts subjected to heat (95110°C, 12 min) from radiofrequency thermal ablation device.(AU)
Biblioteca responsável:
BR68.1
Localização: BR68.1
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