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Redução do uso de animais através da bioinformática: técnicas in-silico apontam alvos moleculares / Reduction in the utilization of animals through bioinformatics: in-silico techniques point towards molecular targets
Pacheco, Christina; Felipe, Stela Mirla da Silva; Vasconcelos Filho, Francisco Sérgio; Santos, Luiz Henrique Pontes dos; Moura, Felipe Carmo de; Alves, Juliana Osório; Queiroz, Adriano Nogueira de; Ceccatto, Vânia Marilande.
Afiliação
  • Pacheco, Christina; Universidade Estadual do Ceará. BR
  • Felipe, Stela Mirla da Silva; Universidade Estadual do Ceará. BR
  • Vasconcelos Filho, Francisco Sérgio; Universidade Estadual do Ceará. BR
  • Santos, Luiz Henrique Pontes dos; Universidade Estadual do Ceará. BR
  • Moura, Felipe Carmo de; Universidade Estadual do Ceará. BR
  • Alves, Juliana Osório; Universidade Estadual do Ceará. BR
  • Queiroz, Adriano Nogueira de; Universidade Estadual do Ceará. BR
  • Ceccatto, Vânia Marilande; Universidade Estadual do Ceará. BR
Ciênc. Anim. (Impr.) ; 25(3): 50-53, 2015. tab
Article em Pt | VETINDEX | ID: biblio-1472218
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT
Model animals are indispensable in the advancement of life sciences. Computational analyses can save time and reduce the number of animals needed. Bioinformatics offer tools that support research through in-silico evaluations. Our aim was to study the function of exercise-linked genes, focusing on disease pathways, envisaging the discovery of new molecular targets for the use in animal model studies. This research was part of two projects approved by the local Ethics Committee (CEUA/UECE) in 04/2014 (1592060/2014) and 07/2015 (2542310/2015). Human genes linked to physical exercise were classified by the pathways using the enrichment tool Enrichnet. Statistical analyses (ANOVA) were used using the Fisher test (q-value). Strong correlations were found with neurodegenerative, cardiovascular and immunologic diseases. Within neurodegenerative diseases, physical exercise was found to be linked to Parkinson’s (q-value 1.6 X10-17), Alzheimer’s (q-value 3.9 X10-16) and Huntington disease (q-value 1.9 X10-15). Within cardiovascular diseases linked to exercise there is hypertrophic cardiomyopathy (q-value 8.5 X10-15). A large number of genes linked to exercise were found to participate in disease linked metabolic pathways. Concluding, after evaluating genes linked to physical exercise and disease pathways, new molecular targets for the use in model animal studies were revealed.
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Texto completo: 1 Base de dados: VETINDEX Idioma: Pt Revista: Ciênc. Anim. (Impr.) / Ciênc. Anim. (Impr.) Ano de publicação: 2015 Tipo de documento: Article
Texto completo: 1 Base de dados: VETINDEX Idioma: Pt Revista: Ciênc. Anim. (Impr.) / Ciênc. Anim. (Impr.) Ano de publicação: 2015 Tipo de documento: Article