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The aplication of cyanoacrilate surgical glue on skin suture in rats

Ilgenfritz Neto, João; Aydos, Ricardo Dutra; Silva, Iandara Schettert; Ramalho, Rondon Tosta; Ilgenfritz Júnior, João; Campos, Gerson Gattats Orro de; Nakamura, Ricardo Kenithi; Guerisoli, Danilo M. Zanello; Cantero, Wilson de Barros.
Acta cir. bras.; 32(1): 56-64, Jan. 2017. tab, ilus
Artigo em Inglês | VETINDEX | ID: vti-15838


Purpose: To compare the use of a new cyanoacrylate-based surgical glue and suture with sepa-rate points in skin wounds closure. Methods: Thirty-six rats were subjected to a 4cm dorsal longitudinal incision. Twelve were sub-jected to simple suture with polyamide 6-0, 12 rats underwent wall synthesis using Dermabond(r) and 12 was performed cutaneous synthesis with N-2-Butyl-Cyanoacrylate. Twelve of each group was euthanized on the seventh postoperative day, their blood was taken to biochemical tests and a layer of skin and subcutaneous tissue surrounding the surgical scar was randomly divided in two segments, to the submission of tension tests and to histological study. Results: There were no significant difference between groups (p>0.05). In the soft dermis there was more type I collagen production in group I (p 0.05), group II and III was similar re-sults (p>0.05). In the compact dermis, all 3 groups showed similar results (p>0.05). The biomechanical study was similarity between the glue groups (p>0.05) but the group III proved to be different from the others having a higher resistance (p>0.05) . Conclusion: This glue does not cause any inflammation or kidney and hepatic toxicity. Polyamide sutures are more resistant and the glue should be used alone only in less tension are-as.(AU)
Biblioteca responsável: BR68.1
Localização: BR68.1