Bacteremia and meningitis caused by OXA-23-producing Acinetobacter baumannii molecular characterization and susceptibility testing for alternative antibiotics
Schuertz, Kamile Francine; Tuon, Felipe Francisco; Palmeiro, Jussara Kasuko; Conte, Danieli; Telles, João Paulo Marochi; Trevisoli, Lucas Eduardo; Dalla-Costa, Libera Maria.
Braz. J. Microbiol.;
49(supl 1): 199-204, 2018. tab, graf
Artigo
em Inglês
| VETINDEX
| ID: vti-16505
Resumo
Background:Carbapenem-resistant Acinetobacter baumannii infection is a concern in developing countries due to high incidence, few therapeutic options, and increasing costs.Objective:Characterize and analyze the antibiotic susceptibility patterns of carbapenem-resistant A. baumannii isolates and evaluate clinical data of meningitis and bacteremia caused by this microorganism.Methods:Twenty-six A. baumannii isolates from 23 patients were identified by MALDI-TOF and automated methods and genotyped using pulsed field genotyping electrophoresis. Clinical data and outcomes were evaluated. Susceptibility of isolates to colistin, tigecycline, meropenem, imipenem, and doxycycline was determined.Results:Mortality due to A. baumannii infections was 73.91%; all patients with meningitis and 7/8 patients with ventilator-associated pneumonia died. All isolates were susceptibility to polymyxin (100%; MIC50, MIC90: 1 µg/mL, 1 µg/mL) and colistin (100%; MIC50, MIC90: 2 µg/mL, 2 µg/mL), and 92% were susceptible to tigecycline (MIC50, MIC90: 1 µg/mL, 1 µg/mL) and doxycycline (MIC50, MIC90: 2 µg/mL, 2 µg/mL). bla OXA-23 was identified in 24 isolates. Molecular typing showed 8 different patterns: 13 isolates belonged to pattern A (50%).Conclusion:Carbapenem-resistant A. baumannii infections mortality is high. Alternative antimicrobial therapy (doxycycline) for selected patients with carbapenem-resistant A. baumannii infection should be considered.(AU)
Biblioteca responsável:
BR68.1
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