Prevention of rocuronium induced mast cell activation with prophylactic oleuropein rich diet in anesthetized rabbits
Acta cir. bras.
; 33(11): 954-963, Nov. 2018. ilus, tab
Article
em En
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| ID: vti-17291
Biblioteca responsável:
BR68.1
ABSTRACT
Purpose:
The effect of a prophylactic oleuropein-rich diet before anesthesia accompanied by the widely-used steroid-based neuromuscular drug rocuronium on mast cell activation was investigated in the study.Methods:
14 rabbits used in the study. The rabbits in the oleuropein group were given oleuropein-rich extract added to the animals water at doses of 20 mg/kg oleuropein for 15 days orally. After 15 days, all rabbits in the two groups were given general anesthesia with rocuronium of 1 mg/kg. After 1 day, animals were sacrificed and the liver tissue sections stained with H&E, toluidine blue and tryptase for immunohistochemical study.Results:
There was no statistically significant difference between ALT, AST and albumin averages of the oleuropein and control groups (p> 0.05). The tryptase average of the control group was higher than the tryptase average of the oleuropein group and this difference was statistically significant (p=0.003). The T. blue average in the oleuropein group was higher than the control group. However, there was no statistically significant difference between groups (p=0.482).Conclusions:
Rocuronium adverse effects, like hypersensitivity and anaphylaxis, may limit routine use of this substance. The use of oleuropein reduced the number of inflammatory cells and prevented degranulation.(AU)Palavras-chave
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Base de dados:
VETINDEX
Idioma:
En
Revista:
Acta cir. bras.
Ano de publicação:
2018
Tipo de documento:
Article