Alternative animal model for studies of total skin thickness burns
Andrade, Ana Laura Martins de; Parisi, Julia Risso; Brassolatti, Patrícia; Parizotto, Nivaldo Antonio.
Acta cir. bras.;
32(10): 836-842, Oct. 2017. ilus, tab
Artigo
em Inglês
| VETINDEX
| ID: vti-17321
Resumo
Purpose: To present an alternative experimental model of third degree burn of easy reproducibility. Methods: Eighteen male Wister rats were randomly divided into three groups, 6 of which were allocated to each group. A soldering iron coupled to an aluminum plate was used to produce burn, at a temperature of 150ºC, with different exposure times per group. Group 5 (G5) animals were burned at 150°C with exposure time of 5 seconds; Group 10 (G10) the animals were burned at 150°C with exposure time of 10 seconds and group 15 (G15) the animals were burned at 150°C with exposure time of 15 seconds. Results: Histopathological analyzes showed that all three groups had similar morphological characteristics, with total thickness involvement. Conclusion: The technique is effective to reproduce a third degree burn and suggests the temperature of 150ºC with 5 seconds of exposure in order to minimize the risks to the animals.(AU)
Biblioteca responsável:
BR68.1
Localização: BR68.1
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