A study on reducing the absorption of lidocaine from the airway in cats

ABSTRACT

Purpose: To determine if the combination of lidocaine with epinephrine or gamma globulin would decrease the rate or reduce the amount of local absorption of lidocaine through the airway. Methods: Twenty adult male cats were randomly and evenly distributed into four groups 1) Group LG lidocaine administered with gamma globulin; 2) Group LS lidocaine administered with physiological saline); 3) Group LE lidocaine administered with epinephrine; 4) Group C control group. Invasive blood pressure, heart rate, and concentration of lidocaine were recorded before and after administration. Results: The peak of plasma concentrations appeared difference (Group LG 1.39 ± 0.23 mg/L; Group LS 1.47 ± 0.29 mg/L and Group LE 0.99 ± 0.08 mg/L). Compared to Group C, there were significant differences in the average heart rate of Groups LG, LS, and LE (P 0.05). The average systolic blood pressures were significantly different when each group was compared to Group C (P 0.05). The biological half-life, AUC0-120, peak time, and half-life of absorption among the three groups have not presented statistically significant differences (P > 0.05). Conclusion: Administering lidocaine in combination with gamma globulin through airway causes significant decrease the rate and reduce the amount of local absorption of lidocaine in cats.(AU)