Influence of tramadol on functional recovery of acute spinal cord injury in rats
Chaves, Rosa Helena de Figueiredo; Souza, Celice Cordeiro de; Furlaneto, Ismari Perini; Teixeira, Renan Kleber Costa; Oliveira, Carolina Pinheiro de; Rodrigues, Emanuelle de Matos; Santos, Daniel Arthur Santos dos; Silva, Renata Cunha; Penha, Nelson Elias Abrahão da; Lima, Ana Rita de.
Acta cir. bras.;
33(12): 1087-1094, Dec. 2018. tab, graf
Artigo
em Inglês
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| ID: vti-18535
Resumo
Purpose:To evaluate the influence tramadol on functional recovery of acute spinal cord injury in rats.Methods:Ten rats were divided into two groups (n = 5). All animals were submitted by a laminectomy and spinal cord injury at eighth thoracic vertebra. In control group, the rats didnt receive any analgesic. In tramadol group, the rats received tramadol 4mg/Kg at 12/12h until 5 days by subcutaneous. Animals were following by fourteen days. Was evaluated the Basso, Beattie, Bresnahan scale (locomotor evaluation) and Rat Grimace Scale (pain evaluation) at four periods.Results:There no difference between the groups in locomotor evaluation in all periods evaluated (p>0.05) and in both groups there was a partial recover of function. The tramadol group show a lower pain levels at the first, third and seventh postoperatively days when comparing to the control group.Conclusion:The tramadol as an analgesic agent dont influence on functional recovery of acute spinal cord injury in rats.(AU)
Biblioteca responsável:
BR68.1
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