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Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass

Machado, Francisco Heine Ferreira; Castro Filho, Heladio Feitosa de; Babadopulos, Rodrigo Feitosa de Albuquerque Lima; Rocha, Hermano Alexandre Lima; Rocha, José Lima de Carvalho; Moraes Filho, Manoel Odorico de; Costa, Maria da Conceição Cavalcante.
Acta cir. bras.; 34(1): e20190010000009, Feb. 14, 2019. ilus, tab
Artigo em Inglês | VETINDEX-Express | ID: vti-18656


Purpose:To evaluate the contribution of ursodeoxycholic acid (UDCA) in the first 12 months after Roux-en-Y gastric bypass in the prevention of gallstone formation.Methods:A community-based clinical trial was conducted. A total of 137 patients were included in the study; 69 were treated with UDCA, starting 30 days after the surgery, at a dose of 150 mg twice daily (300 mg/day) over a period of 5 consecutive months (GROUP A), and 68 were control patients (GROUP B). The patients were followed-up, and ultrasonography was performed to determine the presence of gallstones at various times during follow-up. Demographic, anthropometric and comorbid indicators were obtained. The data were subjected to normality tests and evaluated using appropriate tests.Results:Patients did not differ in their baseline characteristics. Of the 69 patients who used UDCA, only one patient developed cholelithiasis (1%), whereas 18 controls (26%) formed gallstones (OR = 24.4, p <0.001). Also, other factors were found not to influence the formation of calculi, such as pre-operative or postoperative hepatic steatosis or diabetes (p = 0.759, 0.468, 0.956).Conclusion:The results demonstrated that patients who did not use UDCA showed a 24.4-fold greater probability of developing cholelithiasis.(AU)
Biblioteca responsável: BR68.1