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Phylogenetic and pathotypic characterization of a Newcastle disease virus strain isolated from ducks and pigeons in Hubei, China

Wang, Y; Zhang, H; Gu, C; Cheng, G; Zhang, W; Mehmood, K; Hu, X.
R. bras. Ci. avíc.; 20(1): 145-151, jan.-mar. 2018. ilus, mapas, tab
Artigo em Inglês | VETINDEX | ID: vti-18697


Newcastle disease is a highly contagious disease responsible for major outbreaks and considerable economic losses in the poultry industry in China. There is still little information available regarding gene characterization of the NDV, especially in ducks and pigeons. Therefore, the aim of this study was to investigate NDV isolated from ducks and pigeons in Hubei, China. In this study, three NDVs from ducks and pigeons were isolated between 2013 and 2015.The fusion protein (F) gene of the NDV isolates was sequenced and phylogenetically analyzed. The clinical signs and gross histopathological lesions were examined. Phylogenetic analysis of these strains indicated that all the sequences are classified as genotype II. The isolates shared a 112 G-R-Q-G-R-L 117motif at the F protein cleavage site, indicating that these three isolates strains are lentogenic. Necropsy and histopathology showed the typical pathological changes. It was concluded that commercial ducks and pigeons in Hubei province carry lentogenic NDV strains with regular genetic divergence, indicating that these species may act as the main reservoirs of NDV in poultry. Therefore, strategies and surveillance should be undertaken to reduce the risk of ND outbreaks.(AU)
Biblioteca responsável: BR68.1