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Immunhistochemical analysis of Nuclear Factor Kappa Beta expression in etiopathogenesis of ovarian tumors
Yilmaz, Ercan; Gul, Mehmet; Melekoglu, Rauf; Koleli, Isil.
Afiliação
  • Yilmaz, Ercan; Inonu University. Faculty of Medicine. Department of Obstetrics and Gynecology. Malatya. Turkey
  • Gul, Mehmet; Inonu University. Faculty of Medicine. Department of Histology and Embriyology. Malatya. Turkey
  • Melekoglu, Rauf; Inonu University. Faculty of Medicine. Department of Obstetrics and Gynecology. Malatya. Turkey
  • Koleli, Isil; Inonu University. Faculty of Medicine. Department of Obstetrics and Gynecology. Malatya. Turkey
Acta cir. bras. ; 33(7): 641-650, jul. 2018. tab, ilus
Article em En | VETINDEX | ID: vti-19253
Biblioteca responsável: BR68.1
ABSTRACT

Purpose:

To investigate the place of the transcription factor nuclear kappa B (NF-kB), which is a marker of chronic inflammation, in the etiology of the ovarian carcinoma.

Methods:

NFkB analysis with the immunohistochemical method has been performed. To evaluate immunohistochemical NF-kB expression in the ovarian tissue, the H-score method. H-score = Pi (i+1), where Pi is the percentage of stained cells in each intensity category (0-100%) and i is the intensity indicating weak (i=1), moderate (i=2) or strong staining (i=3).

Results:

It has been seen that, the mean H score is statistically significantly higher in the patient group with serous and musinous adenocarcinoma diagnosis than the two other patient groups (p 0.005).

Conclusions:

Factor nuclear kappa B is an important mediator that acts in the chronic inflammation. The highest expression rates are determined by the immunohistochemical method in the ovarian cancer group.(AU)
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