Immunhistochemical analysis of Nuclear Factor Kappa Beta expression in etiopathogenesis of ovarian tumors
Yilmaz, Ercan; Gul, Mehmet; Melekoglu, Rauf; Koleli, Isil.
Acta cir. bras.;
33(7): 641-650, jul. 2018. tab, ilus
Artigo
em Inglês
| VETINDEX
| ID: vti-19253
Resumo
Purpose: To investigate the place of the transcription factor nuclear kappa B (NF-kB), which is a marker of chronic inflammation, in the etiology of the ovarian carcinoma. Methods: NFkB analysis with the immunohistochemical method has been performed. To evaluate immunohistochemical NF-kB expression in the ovarian tissue, the H-score method. H-score = Pi (i+1), where Pi is the percentage of stained cells in each intensity category (0-100%) and i is the intensity indicating weak (i=1), moderate (i=2) or strong staining (i=3). Results: It has been seen that, the mean H score is statistically significantly higher in the patient group with serous and musinous adenocarcinoma diagnosis than the two other patient groups (p 0.005). Conclusions: Factor nuclear kappa B is an important mediator that acts in the chronic inflammation. The highest expression rates are determined by the immunohistochemical method in the ovarian cancer group.(AU)
Biblioteca responsável:
BR68.1
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