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The role of oxymatrine in regulating TGF-beta1 in rats with hepatic fibrosis
Wu, Jing; Pan, Lin; Jin, Xueqin; Li, Weihua; Li, Hongbing; Chen, Jianmao; Yang, Wen.
Afiliação
  • Wu, Jing; Ningxia Medical University. Laboratory Animal Center. Yinchuan. China
  • Pan, Lin; Affiliated Hospital of Ningxia Medical University. Yinchuan. China
  • Jin, Xueqin; Ningxia Medical University. Laboratory Animal Center. Yinchuan. China
  • Li, Weihua; Ningxia Medical University. Laboratory Animal Center. Yinchuan. China
  • Li, Hongbing; s.af
  • Chen, Jianmao; Ningxia Medical University. Laboratory Animal Center. Yinchuan. China
  • Yang, Wen; Ningxia Medical University. Laboratory Animal Center. Yinchuan. China
Acta cir. bras. ; 33(3): 207-215, mar. 2018. tab, ilus, graf
Article em En | VETINDEX | ID: vti-19583
Biblioteca responsável: BR68.1
ABSTRACT

Purpose:

To investigate whether oxymatrine (OMT) prevents hepatic fibrosis in rats by regulating liver transforming growth factor β1 (TGF-β1) level.

Methods:

Hepatic fibrosis was induced in rats by thioacetamide (TAA). Blood was collected at the end of week 12 to determine the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and glutathione (GSH). Changes in liver tissue were observed after hematoxylin-eosin (HE) staining.

Results:

Fibrosis was confirmed by Massons collagen staining. Liver TGF-β1 level was determined by ELISA. OMT significantly reduced serum ALT and AST but increased GSH levels in rats with hepatic fibrosis. Moreover, it significantly improved liver histology in rats with TAA-induced hepatic fibrosis. It significantly decreased liver TGF-β1 level compared to that in the untreated group. It also significantly reduced collagen deposition in rats.

Conclusion:

Oxymatrine is effective in protecting rats from thioacetamide-induced hepatic fibrosis by regulating TGF-β1 expression.(AU)
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Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: Acta cir. bras. Ano de publicação: 2018 Tipo de documento: Article / Project document

Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: Acta cir. bras. Ano de publicação: 2018 Tipo de documento: Article / Project document