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Influence of the geometry of nanostructured hydroxyapatite and alginate composites in the initial phase of bone repair

Santos, George Gonçalves dos; Vasconcelos, Luisa Queiroz; Poy, Suelen Cristina da Silva; Almeida, Renata dos Santos; Barbosa Júnior, Aryon de Almeida; Santos, Silvia Rachel de Albuquerque; Rossi, Alexandre Malta; Miguel, Fúlvio Borges; Rosa, Fabiana Paim.
Acta cir. bras.; 34(2): e201900203, Feb. 28, 2019. ilus, tab, graf
Artigo em Inglês | VETINDEX | ID: vti-20589

Resumo

Purpose:To analyze, histomorphologically, the influence of the geometry of nanostructured hydroxyapatite and alginate (HAn/Alg) composites in the initial phase of the bone repair.Methods:Fifteen rats were distributed to three groups: MiHA - bone defect filled with HAn/Alg microspheres; GrHA - bone defect filled with HAn/Alg granules; and DV - empty bone defect; evaluated after 15 days postoperatively. The experimental surgical model was the critical bone defect, ≅8.5 mm, in rat calvaria. After euthanasia the specimens were embedded in paraffin and stained with hematoxylin and eosin, picrosirius and Masson-Goldners trichrome.Results:The histomorphologic analysis showed, in the MiHA, deposition of osteoid matrix within some microspheres and circumjacent to the others, near the bone edges. In GrHA, the deposition of this matrix was scarce inside and adjacent to the granules. In these two groups, chronic granulomatous inflammation was noted, more evident in GrHA. In the DV, it was observed bone neoformation restricted to the bone edges and formation of connective tissue with reduced thickness in relation to the bone edges, throughout the defect.Conclusion:The geometry of the biomaterials was determinant in the tissue response, since the microspheres showed more favorable to the bone regeneration in relation to the granules.(AU)
Biblioteca responsável: BR68.1