The beneficial effects of Montelukast against 2, 3, 7, 8-tetrachlorodibenzo- p -dioxin toxicity in female reproductive system in rats
Melekoglu, Rauf; Ciftci, Osman; Cetin, Aslı; Basak, Nese; Celik, Ebru.
Acta cir. bras.;
31(8): 557-563, Aug. 2016. tab, ilus
Artigo
em Inglês
| VETINDEX
| ID: vti-20927
Resumo
PURPOSE:To determine the toxic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on reproductive system and the beneficial effects of Montelukast (ML) with histological and biochemical analysis.METHODS:Rats were randomly divided into four equal groups (control, TCDD, ML and TCDD+ML). Tissue samples were collected on day 60 and oxidative status and histological alterations were analyzed.RESULTS:The results showed a significant increase in oxidative and histological damage on uterine and ovarian tissues. Otherwise, the oxidative and histological damages caused by TCDD were prevented with ML treatment.CONCLUSION:The toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on female reproductive system were reversed with Montelukast treatment. Therefore, we claimed that ML treatment might be useful for TCDD toxicity.(AU)
Biblioteca responsável:
BR68.1
Localização: BR68.1
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