Noradrenaline and dobutamine effects on the volume expansion with normal saline in rabbits subjected to hemorrhage
Acta cir. bras.
; 31(9): 621-628, Sept. 2016. graf, ilus
Article
em En
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| ID: vti-20933
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BR68.1
Localização: BR68.1
ABSTRACT
PURPOSE:
To evaluate the effects of dobutamine (DB), noradrenaline (NA), and their combination (NADB), on volume retention in rabbits submitted to hemorrhage.METHODS:
Thirty six rabbits were randomly divided into 6 groups SHAM, Control, Saline, DB, NA, DB+NA. All the animals, except for SHAM, were subjected to hemorrhage of 25% of the calculated blood volume. Control animals were replaced with their own blood. The other groups received NSS 3 times the volume withdrawn. The intravascular retention, hematocrit, diuresis, central venous pressure, mean arterial pressure, NGAL, dry-to-wet lung weight ratio (DTWR) and the lung and kidney histology were analyzed.RESULTS:
Replacement with NSS and NA, DB or NA+DB did not produce differences in the intravascular retention. After hemorrhage, the animals presented a significant decrease in the MAP and CVP, which were maintained until volume replacement. Regarding NGAL, dry-to-wet-lung-weight ratio, lung and kidney histology, there were no statistical differences between the groups.CONCLUSION:
The use of noradrenaline, dobutamine or their combination did not increase the intravascular retention of volume after normal saline infusion.(AU)Palavras-chave
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Base de dados:
VETINDEX
Idioma:
En
Revista:
Acta cir. bras.
Ano de publicação:
2016
Tipo de documento:
Article