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Oral or topical administration of L-arginine changes the expression of TGF and iNOS and results in early wounds healing
Jerônimo, Márcio Sousa; Barros, Adria do Prado; Morita, Vinícius Elord Zen; Alves, Erika Oliveira; Souza, Nathalia Lobão Barroso de; Almeida, Rosane Mansan de; Nóbrega, Yanna Karla Medeiros; Cavalcanti Neto, Florêncio Figueiredo; Amorin, Rivadávio; Borin, Maria de Fátima; Bocca, Anamélia Lorenzetti.
Afiliação
  • Jerônimo, Márcio Sousa; Universidade de Brasília. Institute of Biology. Cell Biology Department. Applied Immunology Laboratory. Brazil
  • Barros, Adria do Prado; Universidade de Brasília. Farmaceutic Science Faculty. Brasilia. Brazil
  • Morita, Vinícius Elord Zen; Universidade de Brasília. Farmaceutic Science Faculty. Brasilia. Brazil
  • Alves, Erika Oliveira; Universidade de Brasília. Farmaceutic Science Faculty. Brasilia. Brazil
  • Souza, Nathalia Lobão Barroso de; Universidade de Brasília. Farmaceutic Science Faculty. Brasilia. Brazil
  • Almeida, Rosane Mansan de; Universidade de Brasília. Farmaceutic Science Faculty. Brasilia. Brazil
  • Nóbrega, Yanna Karla Medeiros; Universidade de Brasília. Faculty of Medicine. Pathology Department. Brasilia. Brazil
  • Cavalcanti Neto, Florêncio Figueiredo; Universidade de Brasília. Faculty of Medicine. Pathology Department. Brasilia. Brazil
  • Amorin, Rivadávio; Universidade de Brasília. Farmaceutic Science Faculty. Brasilia. Brazil
  • Borin, Maria de Fátima; Universidade de Brasília. Institute of Biology. Cell Biology Department. Applied Immunology Laboratory. Brasilia. Brazil
  • Bocca, Anamélia Lorenzetti; Universidade de Brasília. Institute of Biology. Cell Biology Department. Applied Immunology Laboratory. Brasilia. Brazil
Acta cir. bras. ; 31(9): 586-596, Sept. 2016. ilus, graf, tab
Article em En | VETINDEX | ID: vti-20935
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT

PURPOSE:

To evaluate the contribution of L-arginine oral or topical rout of administration in the surgical wound healing process.

METHODS:

L-arginine was orally or topically administrated to mice after a laparotomy model procedure. The wounds were analyzed to evaluate the granulation tissue by HE analysis, collagen deposition, iNOS and cytokines production by immunochemisyry on wound progress. Mice used in this model were healthy, immunosupressed or diabetic and all of them were treated with different concentration of L-arginine and rout of administration.

RESULTS:

Suggested that groups treated with L-arginine orally or topically improved wound repair when compared with non-treatad mice. L- arginine treatment stimulated TGF- and restricted NO production leading to a mild Th1 response and collagen deposition in injured area, when it was orally administrated. Topical administration decreased IL-8 and CCR1 expression by wound cells but did not interfere with TNF- and IL-10 production, ratifying the decrease of inflammatory response, the oral administration however, presented a higher iNOS and TGF- expression then. L-arginine treatment also improved the improved the wound healing in immunosupressed or diabetic mice.

CONCLUSION:

L-arginine administrated orally or topically can be considered an important factor in the recuperation of tissues.(AU)
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