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L-carnitine has a protective effect on the colonic mucosa during abdominopelvic radiotherapy in rats
Tas, Sukru; Ozkan, Omer Faruk; Cikman, Oztekin; Kiraz, Asli; Akgun, Yilmaz; Karaayvaz, Muammer.
Afiliação
  • Tas, Sukru; Canakkale Onsekiz Mart University. Faculty of Medicine. Department of General Surgery. Canakkale. Turkey
  • Ozkan, Omer Faruk; Canakkale Onsekiz Mart University. Faculty of Medicine. Department of General Surgery. Canakkale. Turkey
  • Cikman, Oztekin; Van Yuzuncu Yil University. Faculty of Medicine. Department of General Surgery. Van. Turkey
  • Kiraz, Asli; Canakkale Onsekiz Mart University. Faculty of Medicine. Department of Medical Microbiology. Canakkale. Turkey
  • Akgun, Yilmaz; Canakkale Onsekiz Mart University. Faculty of Medicine. Department of General Surgery. Canakkale. Turkey
  • Karaayvaz, Muammer; Canakkale Onsekiz Mart University. Faculty of Medicine. Department of General Surgery. Canakkale. Turkey
Acta cir. bras. ; 31(9): 615-620, Sept. 2016. ilus
Article em En | VETINDEX | ID: vti-20936
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT

PURPOSE:

To evaluate histopathologically the radioprotective effect of L-carnitine on the colonic mucosa in rats undergoing abdominopelvic irradiation.

METHODS:

Thirty-two rats were randomly assigned to four experimental groups intraperitoneal administration of normal saline (group 1) or L-carnitine (300 mL/kg; group 2), followed in groups 3 and 4, respectively, by one dose of abdominopelvic radiation (20 Gy) 30 min later. Rats were sacrificed 5 days after radiation, and their descending colons were resected for histopathological evaluation of the presence and severity of damage.

RESULTS:

Average damage scores did not differ significantly between groups 1 and 2 (0.13 ± 0.35 and 0.25 ± 0.46, respectively); the group 3 score was highest (10.25 ± 0.71), and the group 4 score (3.63 ± 1.41) was significantly lower than that of group 3 (both p = 0.0001). Pre-radiation L-carnitine administration significantly reduced mucosal thinning, crypt distortion, reactive atypia, inflammation, cryptitis, and reactive lymph-node hyperplasia (all p 0.01).

CONCLUSIONS:

L-carnitine had a radioprotective effect on rat colonic mucosa. L-carnitine use should be explored for patients with gastrointestinal cancer, who have reduced serum L-carnitine levels.(AU)
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