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Carcinogenesis in rats subjected to a new model ureterosigmoidostomy and treated with L-lysine
Santos, Alessandra Marques dos; Coelho, João Paulo Ferreira; Juanes, Camila de Carvalho; Azevedo, Rafael Barbosa de; Melo, Nayanna de Oliveira Ramos; Jamacaru, Francisco Vagnaldo Fechine; Dornelas, Conceição Aparecida.
Afiliação
  • Santos, Alessandra Marques dos; Universidade Federal do Ceará. Departamento de Patologia. Fortaleza. Brasil
  • Coelho, João Paulo Ferreira; Universidade Federal do Ceará. Fortaleza. Brasil
  • Juanes, Camila de Carvalho; Universidade Federal do Ceará. Fortaleza. Brasil
  • Azevedo, Rafael Barbosa de; Universidade Federal do Ceará. Fortaleza. Brasil
  • Melo, Nayanna de Oliveira Ramos; Universidade Federal do Ceará. Fortaleza. Brasil
  • Jamacaru, Francisco Vagnaldo Fechine; Universidade Federal do Ceará. Faculdade de Medicina. Núcleo de Pesquisa e Desenvolvimento de Medicamentos. Fortaleza. Brasil
  • Dornelas, Conceição Aparecida; Universidade Federal do Ceará. Departamento de Patologia. Fortaleza. Brasil
Acta cir. bras. ; 31(12): 793-800, Dec. 2016. ilus, tab, graf
Article em En | VETINDEX | ID: vti-20999
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT

PURPOSE:

To evaluate the effects of L-lysine on the intestinal and urothelial epithelium of rats subjected to ureterosigmoidostomy (new model for surgical carcinogenesis).

METHODS:

Forty-two rats, 9 weeks of age, were divided into 6 groups. Animals in groups A, B, C were subjected to ureterosigmoidostomy (US) and treated with L-lysine, celecoxib and H2O, respectively. Groups D, E and F (non-operated controls) received L-lysine, celecoxib and H2O, respectively. The L-lysine dose was 150 mg/kg and that of celecoxib was 20 mg/kg. The colon was analyzed for the presence of aberrant crypt foci (ACF) under a stereomicroscope.The tissue was stained with hematoxylin and eosin and PAS alcian blue.

RESULTS:

There were rare ACF, and there was no statistically significant difference between the groups. Histopathologic study of the ureteral epithelium identified moderate to severe urothelial hyperplasia in rats with ureterosigmoidostomy. Transitional hyperplasia in the ureters of animals receiving L-lysine (A) showed an apparent difference compared to the control (C) (P=0.2424). There was no dysplasia or atypia

CONCLUSION:

L-lysine does not promote carcinogenesis of the intestinal and urethelial epithelium of rats subjected to ureterosigmoidostomy at the doses and times studied.(AU)
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