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Regulation of T lymphocyte subpopulations in specific pathogen-free chickens following experimental fowl adenovirus-VIII infection
Wang, Chun-jie; Yu, Siriguleng; Ao-ri-ge-le; Jia, De-gang; Yao, Hong-qiang; Zhao, Huai-ping; Lillehoj, H. S.; Si-mu-ji-de; Postnikoff, Andrew CL; Xu, Si-ri-gu-leng.
Afiliação
  • Wang, Chun-jie; Inner Mongolia Agricultural University. College of Veterinary Science. Department of Basic Veterinary. Huhhot. China
  • Yu, Siriguleng; Inner Mongolia Agricultural University. College of Veterinary Science. Department of Basic Veterinary. Huhhot. China
  • Ao-ri-ge-le; Inner Mongolia Agricultural University. College of Veterinary Science. Department of Basic Veterinary. Huhhot. China
  • Jia, De-gang; Inner Mongolia Agricultural University. College of Veterinary Science. Department of Basic Veterinary. Huhhot. China
  • Yao, Hong-qiang; Inner Mongolia Agricultural University. College of Veterinary Science. Department of Basic Veterinary. Huhhot. China
  • Zhao, Huai-ping; Inner Mongolia Agricultural University. College of Veterinary Science. Department of Basic Veterinary. Huhhot. China
  • Lillehoj, H. S.; Inner Mongolia Agricultural University. College of Veterinary Science. Department of Basic Veterinary. Huhhot. China
  • Si-mu-ji-de; Inner Mongolia Agricultural University. College of Veterinary Science. Department of Basic Veterinary. Huhhot. China
  • Postnikoff, Andrew CL; Inner Mongolia Agricultural University. College of Veterinary Science. Department of Basic Veterinary. Huhhot. China
  • Xu, Si-ri-gu-leng; Inner Mongolia Agricultural University. College of Veterinary Science. Department of Basic Veterinary. Huhhot. China
Braz. J. Microbiol. ; 43(4): 1281-1290, Oct.-Dec. 2012. graf
Article em En | VETINDEX | ID: vti-2154
Biblioteca responsável: BR1.1
Localização: BR68.1
ABSTRACT
Two-day-old specific pathogen-free (SPF) chickens were divided into two groups. Group I was inoculated orally with fowl adenovirus VIII (FAV-VIII). Group II served as a negative control. Chickens were investigated at various days post-inoculation (dpi) by flow cytometric analysis for changes in T lymphocyte subpopulations in immune system and blood. In the thymus, CD3+ T lymphocytes were increased at 25 dpi, with significant increases in the FAV infected noted at 1, 12, 20dpi (p<0.05). This was accompanied by a corresponding increase of CD4+ and CD8+ T lymphocytes. In the spleen, CD3+ and CD4+ T lymphocytes were increased significantly at 30 dpi (p<0.01) whereas CD8+ and TCR γ δ+ T lymphocytes were decreased at 1 (p<0.05), 30 dpi (p<0.01). An increase of CD3+, CD4+ and CD8+ T lymphocytes was noticed in peripheral blood, and accompanied by a decrease of TCR γ δ+ T lymphocytes. These results demonstrated that infection with FAV-VIII causes significant fluctuations in T lymphocyte subpopulations in thymus, blood and spleen. It can be concluded that an infection with FAV-VIII has profound effects on the immune system, especially on cell mediated immune competency.(AU)
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Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: Braz. J. Microbiol. Ano de publicação: 2012 Tipo de documento: Article / Project document

Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: Braz. J. Microbiol. Ano de publicação: 2012 Tipo de documento: Article / Project document