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Fibrogenesis and epithelial coating of skin wounds in rats treated with angico extract (Anadenanthera colubrina var. cebil)
Pessoa, Wagner Soares; Estevão, Lígia Reis de Moura; Simões, Ricardo Santos; Mendonça, Fábio de Souza; Evêncio-Luz, Luis; Baratella-Evêncio, Liriane; Florencio-Silva, Rinaldo; Sá, Fabrício Bezerra de; Evêncio-Neto, Joaquim.
Afiliação
  • Pessoa, Wagner Soares; Federal University of Piaui. Department of Morphology. Histology Division. Teresina. Brazil
  • Estevão, Lígia Reis de Moura; Federal Rural University of Pernambuco. Department of Morphology and Animal Physiology. Postgraduate Program in Animal Bioscience. Recife. Brazil
  • Simões, Ricardo Santos; Federal University of Sao Paulo. Department of Morphology and Genetic. Postgraduate Program in Morphology. São Paulo. Brazil
  • Mendonça, Fábio de Souza; Federal Rural University of Pernambuco. Department of Morphology. Histology Division. Recife. Brazil
  • Evêncio-Luz, Luis; Federal University of Piaui. Department of Biology. Microbiology Division. Picos. Brazil
  • Baratella-Evêncio, Liriane; Federal Rural University of Pernambuco. Department of Morphology. Histology Division. Recife. Brazil
  • Florencio-Silva, Rinaldo; Federal University of Sao Paulo. Department of Morphology and Genetics. Postgraduate Program in Morphology. São Paulo. Brazil
  • Sá, Fabrício Bezerra de; Federal Rural University of Pernambuco. Department of Morphology and Physiology. Anatomy Division. Recife. Brazil
  • Evêncio-Neto, Joaquim; Federal Rural University of Pernambuco. Department of Morphology and Physiology. Histology Division. Recife. Brazil
Acta cir. bras. ; 30(5): 353-358, May 2015. ilus, graf
Article em En | VETINDEX | ID: vti-22935
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT

PURPOSE:

To evaluate the effects of angico bark extract (Anadenanthera colubrina var. cebil) in the healing process of the skin of rats.

METHODS:

Twenty adult male rats were divided into four groups of five animals each, according to the respective postoperative days, as follow G4, G7, G14 and G21. Each group received two incisions on skin and subcutaneous tissue in the right and left antimere of the thoracic region, separated by a distance of 2 cm. The right lesion was treated daily with saline and the left with the angico alcoholic extract (5%). At the end of each experimental period, the animals were euthanized and fragments of the wound area with the edges were removed, fixed in 10% formaldehyde solution and processed for paraffin embedding. Histological sections (5 m of thickness) were stained with hematoxylin and eosin (HE), Gomori trichromic and picrosisirus red for morphological and morphometric analyses. Statistical analysis was done by ANOVA and Tukey-Kramer test (p 0.05).

RESULTS:

Morphological analysis showed larger fibroblasts and a higher concentration of collagen fibers in skyn wounds treated with the angico extract. Morphometric analysis demonstrated a significant increase in the number of fibroblasts at 7th and collagen in 7th and 14th days (p 0.01) in wounds treated with the angico extract.

CONCLUSION:

The angico alcoholic extract (Anadenanthera colubrina var. cebil) induces the acceleration of wound healing in skin wounds of rats.(AU)
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