The antioxidant effect of dexmedetomidine on testicular ischemia-reperfusion injury
Tuglu, Devrim; Yuvanc, Ercan; Ylmaz, Erdal; Yazici Gencay, Isin; Atasoy, Pinar; Kisa, Ucler; Batislam, Ertan.
Acta cir. bras.;
30(6): 414-421, June 2015. tab, ilus
Artigo
em Inglês
| VETINDEX
| ID: vti-23131
Resumo
PURPOSE:To investigate the protective effect of dexmedetomidine (Dex) on testicular damage induced by ischemia-reperfusion injury in rats.METHODS:Sham group underwent left scrotal exploration only (group 1). The ischemia-reperfusion only group underwent left testicular torsion and detorsion (group 2). The ischemia-reperfusion plus Dex group underwent left testicular torsion, received 50 µg/kg Dex (group 3) and 100 µg/kg Dex (group 4) intraperitoneally at minute 180 of ischemia and then underwent detorsion. We determined histopathological findings and performed specific biochemical analyses.RESULTS:Increasing doses of Dex significantly increased TAS, and significantly decreased OSI. Analyzing the antioxidant effects of increasing doses of Dex in torsion and contrlateral testicles: Dex 100 µg/kg statistically significant increased the tissue total antioxidant status (TAS) and oxidative stress index (OSI) when compared with Dex 50 µg/kg but not found significantly change on the tissue total oxidant status (TOS). However, Dex did not significantly improve these histological alterations.CONCLUSION:The antioxidant effects of dexmedetomidine on testicular ischemia-reperfusion injury in ipsilateral and contrlateral testis, but in the histopathological level, there was no difference statistically according to Johnsen's scoring system between groups at both sides.(AU)
Biblioteca responsável:
BR68.1
Localização: BR68.1
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