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Myocardial contractility impairment with racemic bupivacaine, non-racemic bupivacaine and ropivacaine. A comparative study
Pinotti, Matheus Fécchio; Hepner, Adriana; Campos, Dijon Henrique Salomé; Silva, Leopoldo Muniz; Cicogna, Antonio Carlos; Ganem, Eliana Marisa.
Afiliação
  • Pinotti, Matheus Fécchio; Universidade Estadual de São Paulo. Botucatu School of Medicine. Department of Anesthesiology. Botucatu. Brazil
  • Hepner, Adriana; Universidade Estadual de São Paulo. Botucatu School of Medicine. Department of Anesthesiology. Botucatu. Brazil
  • Campos, Dijon Henrique Salomé; Universidade Estadual de São Paulo. Botucatu School of Medicine. Department of Internal Medicine. Botucatu. Brazil
  • Silva, Leopoldo Muniz; Universidade Estadual de São Paulo. Botucatu School of Medicine. Department of Anesthesiology. Botucatu. Brazil
  • Cicogna, Antonio Carlos; Universidade Estadual de São Paulo. Botucatu School of Medicine. Department of Internal Medicine. Botucatu. Brazil
  • Ganem, Eliana Marisa; Universidade Estadual de São Paulo. Botucatu School of Medicine. Department of Anesthesiology. Botucatu. Brazil
Acta cir. bras. ; 30(7): 484-490, July 2015. graf
Article em En | VETINDEX | ID: vti-23172
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT

PURPOSE:

To study racemic bupivacaine, non-racemic bupivacaine and ropivacaine on myocardial contractility.

METHODS:

Isolated Wistar papillary muscles were submitted to 50 and 100 mM racemic bupivacaine (B50 and B100), non-racemic bupivacaine (NR50 and NR100) and ropivacaine (R50 and R100) intoxication. Isometric contraction data were obtained in basal condition (0.2 Hz), after increasing the frequency of stimulation to 1.0 Hz and after 5, 10 and 15 min of local anesthetic intoxication. Data were analyzed as relative changes of variation.

RESULTS:

Developed tension was higher with R100 than B100 at D1 (4.3 ± 41.1 vs -57.9 ± 48.1). Resting tension was altered with B50 (-10.6 ± 23.8 vs -4.7 ± 5.0) and R50 (-14.0 ± 20.5 vs -0.5 ± 7.1) between D1 and D3. Maximum rate of tension development was lower with B100 (-56.6 ± 38.0) than R50 (-6.3 ± 37.9) and R100 (-1.9 ± 37.2) in D1. B50, B100 and NR100 modified the maximum rate of tension decline from D1 through D2. Time to peak tension was changed with NR50 between D1 and D2.

CONCLUSIONS:

Racemic bupivacaine depressed myocardial contractile force more than non-racemic bupivacaine and ropivacaine. Non-racemic and racemic bupivacaine caused myocardial relaxation impairment more than ropivacaine.(AU)
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Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: Acta cir. bras. Ano de publicação: 2015 Tipo de documento: Article / Project document

Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: Acta cir. bras. Ano de publicação: 2015 Tipo de documento: Article / Project document