Expression of Sphingosine-1-phosphate (S1P) on the cerebral vasospasm after subarachnoid hemorrhage in rabbits
Tang, Hua; Zhao, Donggang; Chen, Shaojun; Fang, Ming; Wang, Feifan; Cui, Ying; Tang, Na; Chen, Qianxue.
Acta cir. bras.;
30(10): 654-659, Oct. 2015. ilus, graf
Artigo
em Inglês
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| ID: vti-23342
Resumo
To demonstrate the relationship between of sphingosine-1-phosphate (S1P) expression and subarachnoid hemorrhage (SAH). METHODS: The basilar arteries from a "double-hemorrhage" rabbit model of SAH were used to investigate the relation between S1P expression and SAH. Various symptoms, including blood clots, basilar artery cross-sectional area, and S1P phosphatase expression were measured at day 3, 5, 7, 9. RESULTS: The expression of S1P was enhanced in the cerebral vasospasm after subarachnoid hemorrhage in the rabbits. And S1P expression was consistent with the basilar artery cross-sectional area changes at day 3, 5, 7, 9. CONCLUSION: Sphingosine-1-phosphate expression in the cerebral arterial may be a new indicator in the development of cerebral vasospasm after subarachnoid hemorrhage and provide a new therapeutic method for SAH.(AU)
Biblioteca responsável:
BR68.1
Localização: BR68.1
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