Rutin ameliorates methotrexate induced hepatic injury in rats
Erdogan, Esra; Ilgaz, Yasin; Gurgor, Pinar Naile; Oztas, Yesim; Topal, Turgut; Oztas, Emin.
Acta cir. bras.;
30(11): 778-784, Nov. 2015. tab, ilus
Artigo
em Inglês
| VETINDEX
| ID: vti-23345
Resumo
To investigate the possible protective effect of rutin on methotrexate induced hepatotoxicity in rats. METHODS: Twenty-two rats were divided into three experimental groups; Control-saline, Mtx, Mtx+Rutin. Hepatic tissue was taken for histological assessment and biochemical assays. Oxidative stress parameters malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were investigated. Liver markers aspartate aminotransferase (AST), alanine aminotransferase (ALT) were analyzed in serum. RESULTS: Mtx+Rutin group showed lower histological injury compared to Mtx group, MDA and ALT levels were increased, while SOD and GSH-Px were decreased in Mtx group compared with Control-saline group. MDA and ALT levels were increased, while SOD and GSH-Px were decreased in Mtx group, compared with Mtx +Rutin group. Serum AST levels were similar among the groups. CONCLUSION: Rutin may be a potential adjuvant drug to reduce the hepatic side effects observed during Mtx therapy for various clinical conditions.(AU)
Biblioteca responsável:
BR68.1
Localização: BR68.1
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