Avaliação da toxicidade gestacional do látex de Himatanthus sucuuba (Spruce) Woodson m camundongos fêmeas Swiss e avaliação da progênie / Evaluation of gestational toxicity of latex of Himatanthus sucuuba (Spruce) Woodson in the female Swiss mice and evaluation of progeny

ABSTRACT

It aimed to investigate the possible effects of the oral administration of the latex diluted of H. sucuuba(LdHs) on pregnancy in the female Swiss mice and evaluation of progeny. We used 54 female mice pregnantwomen in the evaluation protocol gestational toxicity and progeny. Females received the LdHs by gavage during8th to 12th day of gestation and during late pregnancy were euthanized for the observation of gestationalparameters and evaluation of the fetuses. None of LdHs doses interfered negatively on gestational parametersinvestigated or ossification of fetuses, and also did not cause visceral malformations in the offspring. Therefore, thetested doses of LdHs did not cause gestational toxicity in female mice as well as did not interfere in the progeny.(AU)