Avaliação do ciclo estral e da toxicidade sistêmica do látex de Himatanthus sucuuba (Spruce) Woodson em ratas Wistar / The estrous cycle evaluation and systemic toxicity in the latex of Himatanthus sucuuba (Spruce) Woodson in Wistar rats

ABSTRACT

It aimed to investigate the possible effects induced by the diluted latex oral administration of H. sucuuba(LdHs) in Wistar rats on the estrous cycle and other organ systems. The Wistar rats received by gavage the LdHs.The results showed that there was a decrease in average daily intake and ponderable development negativeinterference in the group treated with the dose 100 mg / kg. The number of primary follicles and in the dose 100 mg/ kg LdHs was superior to the control group. It was also observed a decrease in the number of estrous cycles andan increase in the average duration of the estrous cycle in this group. Therefore, doses 25 and 50 mg / kg of LdHshave been shown safe, however the dose 100 mg / kg decreased reproductive efficiency and promoted a lowsystemic toxicity as caused a decrease in feed consumption and interfered with the ponderable development.(AU)