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Efeito do extrato etanólico de Simarouba versicolor em padrões reprodutivos de camundongos e no desenvolvimento embriofetal / Effect of ethanol extract of Simarouba versicolor in reproductive patterns of mice and embryo development

Cunha, Ana Paula Gomes Pereira; Cavalcante, Ykro Talvanis Duarte; Oliveira, Moema Sousa De; Fernandes, Rozeverter Moreno; Fernandes, Maria Zenaide De Lima Chagas Moreno.
R. bras. Reprod. Anim.; 40(4): 602-604, Out-Dez. 2016. ilus, tab
Artigo em Português | VETINDEX | ID: vti-24295

Resumo

Simarouba versicolor has several proven biological activities, however little is known regarding effectson reproduction, so this study evaluated the effect of the ethanol extract of S. versicolor (EOH-Sv) embryofoetaldevelopment. It used to females pregnant randomly assigned into three groups receiving the extract of S.versicolor in doses of 5mg, 10mg and 20mg and a control group (-) received DMSO (3%) from the 8th to 12thday of gestation. The half of the fetuses was set at Bodian for visceral analysis, while the other half fixed informalin (5%) and subjected to alizarin red technique. The EOH-Sv at doses of 20 and 10mg caused abortionand death of the females and the dose of 5mg/kg was able to reduce the number of live fetuses compared tocontrols, there was an increase in the loss rate after implantation (46,03%) even with 90% of implantation. ThusEOH-Sv demonstrated maternal and fetal gestational toxicity.(AU)
Biblioteca responsável: BR68.1
Localização: BR68.1