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Samsum ant venom modulates the immune response and redox status at the acute toxic dose in vivo
Ebaid, Hossam; Abdel-Salam, Bahaa; Alhazza, Ibrahim; Al-Tamimi, Jameel; Hassan, Iftekhar; Rady, Ahmed; Mashaly, Ashraf; Mahmoud, Ahmed; Sammour, Reda.
Afiliação
  • Ebaid, Hossam; King Saud University. College of Science. Department of Zoology. Riyadh. Saudi Arabia
  • Abdel-Salam, Bahaa; Shaqra University. College of Science and Humanities in El-Quwiaya. Department of Biology. Saudi Arabia
  • Alhazza, Ibrahim; King Saud University. College of Science. Department of Zoology. Riyadh. Saudi Arabia
  • Al-Tamimi, Jameel; King Saud University. College of Science. Department of Zoology. Riyadh. Saudi Arabia
  • Hassan, Iftekhar; King Saud University. College of Science. Department of Zoology. Riyadh. Saudi Arabia
  • Rady, Ahmed; King Saud University. College of Science. Department of Zoology. Riyadh. Saudi Arabia
  • Mashaly, Ashraf; King Saud University. College of Science. Department of Zoology. Riyadh. Saudi Arabia
  • Mahmoud, Ahmed; King Saud University. College of Science. Department of Zoology. Riyadh. Saudi Arabia
  • Sammour, Reda; King Saud University. College of Science. Department of Zoology. Riyadh. Saudi Arabia
J. Venom. Anim. Toxins incl. Trop. Dis. ; 25: e.20190020, Dec. 2, 2019. ilus, tab, graf
Article em En | VETINDEX | ID: vti-24695
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT

Background:

Ant venoms express surface molecules that participate in antigen presentation involving pro- and anti-inflammatory cytokines. This work aims to investigate the expression of MHC-II, CD80 and CD86 on the polymorphonuclear cells (PMNs) in rats injected with samsum ant venom (SAV).

Methods:

Rats were divided into three groups - control, SAV-treated (intraperitoneal route, 600 μg/kg), and SAV-treated (subcutaneous route, 600 μg/kg). After five doses, animals were euthanized and samples collected for analysis.

Results:

The subcutaneous SAV-trated rats presented decreased levels of glutathione with increased cholesterol and triglyceride levels. Intraperitoneal SAV-treated animals displayed significantly reduced concentrations of both IFN-γ and IL-17 in comparison with the control group. However, intraperitoneal and subcutaneous SAV-treated rats were able to upregulate the expressions of MHC-II, CD80 and CD86 on PMNs in comparison with the control respectively. The histological examination showed severe lymphocyte depletion in the splenic white pulp of the intraperitoneal SAV-injected rats.

Conclusion:

Stimulation of PMNs by SAV leads to upregulation of MHC-II, CD 80, and CD 86, which plays critical roles in antigen presentation and consequently proliferation of T-cells. Subcutaneous route was more efficient than intraperitoneal by elevating MHC-II, CD80 and CD86 expression, disturbing oxidative stability and increasing lipogram concentration.(AU)
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Texto completo: 1 Base de dados: VETINDEX / LILACS Idioma: En Revista: J. Venom. Anim. Toxins incl. Trop. Dis. / J. venom. anim. toxins incl. trop. dis Ano de publicação: 2019 Tipo de documento: Article / Project document

Texto completo: 1 Base de dados: VETINDEX / LILACS Idioma: En Revista: J. Venom. Anim. Toxins incl. Trop. Dis. / J. venom. anim. toxins incl. trop. dis Ano de publicação: 2019 Tipo de documento: Article / Project document