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A Brazilian pulp and paper mill effluent disrupts energy metabolism in immature rat testis and alters Sertoli cell secretion and mitochondrial activity
Oliveira, Vanessa Staldoni de; Castro, Allisson Jhonatan Gomes; Domingues, Juliana Tonietto; Souza, Ariane Zamoner Pacheco de; Scheffer, Débora da Luz; Latini, Alexandra; Soares, Carlos Henrique Lemos; Kraak, Glen Van Der; Silva, Fátima Regina Mena Barreto.
Afiliação
  • Oliveira, Vanessa Staldoni de; Universidade Federal de Santa Catarina. Departamento de Bioquímica. Florianópolis. BR
  • Castro, Allisson Jhonatan Gomes; Universidade Federal de Santa Catarina. Departamento de Bioquímica. Florianópolis. BR
  • Domingues, Juliana Tonietto; Universidade Federal de Santa Catarina. Departamento de Bioquímica. Florianópolis. BR
  • Souza, Ariane Zamoner Pacheco de; Universidade Federal de Santa Catarina. Departamento de Bioquímica. Florianópolis. BR
  • Scheffer, Débora da Luz; Universidade Federal de Santa Catarina. Departamento de Bioquímica. Florianópolis. BR
  • Latini, Alexandra; Universidade Federal de Santa Catarina. Departamento de Bioquímica. Florianópolis. BR
  • Soares, Carlos Henrique Lemos; Universidade Federal de Santa Catarina. Departamento de Bioquímica. Florianópolis. BR
  • Kraak, Glen Van Der; University of Guelph. Department of Integrative Biology. Guelph. CA
  • Silva, Fátima Regina Mena Barreto; Universidade Federal de Santa Catarina. Departamento de Bioquímica. Florianópolis. BR
Anim. Reprod. (Online) ; 17(2): e20190116, 2020. graf
Article em En | VETINDEX | ID: biblio-1461502
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT
Our objective was to investigate whether the pulp and paper mill industry effluent could affect the testis and Sertoli cells in a fast exposure period. For this, the present study was carried out in immature rats at 10-day-old. Testis treated in vitro with 4% effluent for 1 h presented changes in energy metabolism in terms of a decrease in lactate content and glucose uptake. Elevation in GSH content, as an antioxidant defense mechanism, was also detected. Sertoli cells treated with 4% effluent for 1 hour showed alterations in the mitochondrial metabolism that favor the decoupling of oxidative phosphorylation and the generation of oxygen reactive species and also a time and concentration-dependent delay secretion of acidic vesicles. Our results showed that pollutants present in the pulp and paper mill effluents, in a short time of exposure, are capable of inducing alterations in important metabolic functions in the testis and in Sertoli cells that are crucial for the correct progression of spermatogenesis and fertility.
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