Antimicrobial activity of allylic thiocyanates derived from the Morita-Baylis-Hillman reaction
Braz. J. Microbiol.
; 45(3): 807-812, July-Sept. 2014. ilus, tab
Article
em En
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| ID: vti-28178
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BR68.1
Localização: BR68.1
ABSTRACT
Bacterial resistance to commonly used antibiotics has been recognized as a significant global health issue. In this study, we carried out the screening of a family of allylic thiocyanates for their action against a diversity of bacteria and fungi with a view to developing new antimicrobial agents. Allylic thiocyanates bearing halogenated aryl groups, which were readily obtained in two steps from the Morita-Baylis-Hillman adducts, showed moderate-to-high activity against selective pathogens, including a methicillin-resistant S. aureus (MRSA) strain. In particular cases, methyl (Z)-3-(2,4-dichlorophenyl)-2-(thiocyanomethyl)-2-propenoate exhibited antimicrobial activity comparable to the reference antibiotic Imipenem.
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VETINDEX
Idioma:
En
Revista:
Braz. J. Microbiol.
Ano de publicação:
2014
Tipo de documento:
Article