Comparison of the depth of anesthesia produced with dexmedetomidine-sevoflurane or medetomidine-sevoflurane by using bispectral index monitoring

ABSTRACT

Background: Bispectral index (BIS) monitor was developed to utilize the depth of anesthesia by estimating electroencephalogram (EEG) signals. BIS, which is the numerical value of EEG derivative, is used for evaluation of depression of central nervous system (CNS) in human medicine. The depressive effect of sedative and anaesthetic agents on CNS in human is correlated to BIS. Dexmedetomidine (DEX) is administered as continuous infusion during anesthesia and surgery in humans. DEX is a hypnotic with high selectivity for 2-adrenergic receptors.Materials, Methods & Results: Adult female New Zealand rabbits (mean ± SD body weight 3.8 ± 0.5 kg) were procured from a certified commercial source to use in medical researches. The animal number in each of the two study groups was four, for a total of eight. The rabbits were randomly divided into two equal groups (n = 4). The rabbits DEX group were administered 20 mcg/kg of iv. DEX HCI for premedication. Medetomidine (MED) group was administered 20 mcg/ kg of iv MED for premedication. Induction was provided by 5% of sevoflurane + 4 L/min oxygen via glove mask in the both groups. General anesthesia was maintained with 3% of sevoflurane + oxygen on spontaneous respiration for 30 min. The animals temporomandibular region was shaved; its fat was eliminated with ether before the study. Human sensors were used as BIS sensor consisted of...(AU)