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Quercetin associated with dimethylsulfoxide has a curative effect on experimental colon anastomosis injury
Demir, Ufuk; Edremitliolu, Mustafa; Kanda, Emel; ehitolu, Müerref Hilal; Klnç, Nihal.
Afiliação
  • Demir, Ufuk; Canakkale Onsekiz Mart University. Department of Physiology. Canakkale. Turquia
  • Edremitliolu, Mustafa; Canakkale Onsekiz Mart University. Department of Physiology. Canakkale. Turquia
  • Kanda, Emel; Canakkale Onsekiz Mart University. Department of Physiology. Canakkale. Turquia
  • ehitolu, Müerref Hilal; Canakkale Onsekiz Mart University. Department of Biochemistry. Canakkale. Turquia
  • Klnç, Nihal; Canakkale Onsekiz Mart University. Department of Pathology. Canakkale. Turquia
Acta cir. bras. ; 35(6): e202000602, 2020. graf, tab
Article em En | VETINDEX | ID: vti-30676
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT
Purpose To examine the effects of quercetin on healing of experimental colon anastomosis injury in early and late period. Methods Eighty male Wistar-Albino rats were divided into 8 groups. For all groups, left colons of the rats were resected and for the rest end-to-end anastomosis was performed. Two of the groups for which the experiment protocol was ended on the 3rd and 7th day following the anastomosis were not administered with either quercetin or dimethylsulfoxide DMSO, whereas two other groups were administered with DMSO only, and four other groups were administered with quercetin dissolved in DMSO in doses of 20 and 100 mg/kg during the protocol. At the end of the study, anastomosis line was resected, histopathological evaluation was performed and bursting pressure, malondialdehyde, superoxide dismutase, catalase, and hydroxyproline levels were measured. Results Quercetin significantly increased hydroxyproline, superoxide dismutase, catalase levels, histopathological healing score, bursting pressure values and decreased malondialdehyde level in early period. It also significantly increased superoxide dismutase, catalase, and hydroxyproline levels and decreased malondialdehyde level in late period. Conclusion It was seen that quercetin speeds up the injury healing process and reveals an antioxidant effect, specifically in early period.(AU)
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Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: Acta cir. bras. Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: Acta cir. bras. Ano de publicação: 2020 Tipo de documento: Article